{"id":66,"date":"2017-02-17T14:10:18","date_gmt":"2017-02-17T06:10:18","guid":{"rendered":"http:\/\/www.ithenticate.com.cn\/news\/?p=66"},"modified":"2017-02-17T14:10:18","modified_gmt":"2017-02-17T06:10:18","slug":"%e6%8a%95%e7%a8%bfsci%e8%ae%ba%e6%96%87%ef%bc%8c%e5%a6%82%e4%bd%95%e5%86%99%e4%b8%80%e4%b8%aa%e5%90%b8%e5%bc%95%e4%ba%ba%e7%9a%84%e9%a2%98%e7%9b%ae%e7%a7%91%e7%a0%94%e6%80%9d%e8%b7%af-%e7%ac%ac","status":"publish","type":"post","link":"https:\/\/www.ithenticate.com.cn\/news\/?p=66","title":{"rendered":"\u6295\u7a3fSCI\u8bba\u6587\uff0c\u5982\u4f55\u5199\u4e00\u4e2a\u5438\u5f15\u4eba\u7684\u9898\u76ee+\u79d1\u7814\u601d\u8def \u7b2c\u4e8c\u7bc7"},"content":{"rendered":"

\u5728\u4e0a\u4e00\u7bc7\u6587\u7ae0\u91cc\uff0c\u4ecb\u7ecd\u4e86\u6295\u7a3fSCI\u8bba\u6587\u65f6\uff0c\u5982\u4f55\u5199\u4e00\u4e2a\u5438\u5f15\u4eba\u7684\u6807\u9898\uff0c\uff08\u70b9\u51fb\u9605\u8bfb\uff1a\u300a\u6295\u7a3fSCI\u6587\u7ae0\uff0c\u5982\u4f55\u5199\u4e00\u4e2a\u5438\u5f15\u4eba\u7684\u9898\u76ee +\u79d1\u7814\u601d\u8def\u300b<\/strong><\/a>\uff09\u3002\u4e3b\u8981\u8c08\u5230SCI\u8bba\u6587\u6765\u81ea\u7eaf\u4e34\u5e8a\u8d44\u6599<\/strong>\uff0c\u6ca1\u6709\u4efb\u4f55\u751f\u7269\u5b66\u6307\u6807\uff0c\u91cd\u70b9\u5f3a\u8c03\u4e86\u4e34\u5e8a\u79d1\u7814\u7684\u91cd\u8981\u6027\u3002\u5982\u679c\u6709\u597d\u601d\u8def\u3001\u8bbe\u8ba1\u51fa\u597d\u8bfe\u9898\uff0c \u5373\u4f7f\u6ca1\u6709\u79d1\u7814\u7ecf\u8d39\uff0c\u4ec5\u4ec5\u662f\u5229\u7528\u75c5\u5386\u3001\u6216\u6536\u96c6\u4e34\u5e8a\u91cf\u8868\u8d44\u6599\uff0c\u4e5f\u80fd\u505a\u51fa\u975e\u5e38\u7cbe\u5f69\u7684\u8bfe\u9898\uff0c\u5e76\u53d1\u8868\u7cfb\u5217\u9ad8\u6c34\u5e73SCI\u6587\u7ae0\uff0c\u8fd9\u662f\u5e74\u8f7b\u5b66\u8005\u4eec\u548c\u533b\u751f\u62a4\u58eb\u4eec\u7684\u4e00\u4e2a\u975e\u5e38\u597d\u7684\u52aa\u529b\u65b9\u5411\uff0c\u5e0c\u671b\u5f15\u8d77\u5927\u5bb6\u91cd\u89c6\u3002<\/p>\n

\u672c\u7bc7\u6587\u7ae0\u662f\u4e0a\u4e00\u7bc7\u7684\u59ca\u59b9\u7bc7\uff0c\u4e3b\u8981\u8fdb\u4e00\u6b65\u9610\u8ff0\u5982\u4f55\u5728\u4e34\u5e8a\u8d44\u6599\u7684\u57fa\u7840\u4e0a\uff0c\u5229\u7528\u751f\u7269\u5b66\u6307\u6807<\/strong>\uff0c\u5305\u62ec\u5916\u5468\u8840\u4e2dbiomarkers\u548c\u9057\u4f20\u5b66\u8d44\u6599\u505a\u5206\u6790\u3001\u5199\u6587\u7ae0\uff0c\u5e76\u5199\u51fa\u5438\u5f15\u4eba\u7684\u6807\u9898\u51fa\u6765\uff0c\u8d77\u5230\u753b\u9f99\u70b9\u775b\u7684\u4f5c\u7528\u3002\u540c\u65f6\u8c08\u53ca\u5982\u4f55\u5229\u7528\u751f\u7269\u5b66\u6307\u6807\uff0c\u7ed3\u5408\u4e34\u5e8a\u8d44\u6599\u53bb\u505a\u79d1\u7814\u3002\u8bf7\u5927\u5bb6\u5728\u4ed4\u7ec6\u9605\u8bfb\u6b64\u6587\u7684\u8fc7\u7a0b\u4e2d\uff0c\u91cd\u70b9\u7422\u78e8\u5176\u4e2d\u7684\u79d1\u7814\u601d\u8def\uff0c\u53cd\u590d\u601d\u8003\u4e00\u4e0b\uff0c\u5b66\u4e60\u548c\u638c\u63e1\u79d1\u7814\u601d\u8def\u624d\u662f\u6700\u5b9d\u8d35\u7684\u3002<\/p>\n

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\u00a0 \u00a0\u4e8c\uff0c\u751f\u7269\u5b66\u6307\u6807\u6216\u57fa\u56e0\u578b\u7814\u7a76 \u00a0 \u00a0<\/span><\/strong><\/span><\/section>\n

\u6211\u4eec\u5e38\u5e38\u5728\u4e34\u5e8a\u4e0a\u91c7\u7528case-control\u8bbe\u8ba1\uff0c\u68c0\u6d4b\u67d0\u79cd\u6216\u67d0\u51e0\u79cd\u7cbe\u795e\u75c5\u4eba\u7684\u67d0\u9879\/\u67d0\u4e9b\u751f\u7269\u5b66\u6307\u6807\uff0c\u540c\u65f6\u4e0e\u6b63\u5e38\u7ec4\u5bf9\u7167\uff0c\u53e6\u5916\u68c0\u6d4b\u57fa\u56e0\u578b\u7684\u7814\u7a76\u4e0e\u6b64\u7c7b\u4f3c\u3002\u6211\u4eec\u76f8\u5173\u6587\u7ae0\u7684\u9898\u76ee\u5982\u4e0b\uff1a<\/p>\n<\/section>\n

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2.1. \u5355\u7eaf\u75c5\u4eba\u7ec4vs \u6b63\u5e38\u7ec4\uff08\u6ca1\u6709\u68c0\u6d4b\u4e34\u5e8a\u75c7\u72b6\u548c\/\u6216\u8ba4\u77e5\uff09\uff1a<\/strong><\/p>\n<\/section>\n<\/section>\n

\u8fd9\u79cd\u7814\u7a76\u5728\u4e34\u5e8a\u4e0a\u6bd4\u8f83\u5e38\u89c1\uff0c\u5c31\u662f\u7eb3\u5165\u4e00\u7ec4\u6216\u51e0\u7ec4\u75c5\u4eba+\u6b63\u5e38\u7ec4\uff0c\u7136\u540e\u68c0\u6d4b\u67d0\u9879\/\u51e0\u9879\u751f\u7269\u5b66\u6307\u6807\uff0c\u6bd4\u8f83\u5355\u7eaf\u7684case-control \u7814\u7a76\uff0c\u7edf\u8ba1\u5206\u6790\u4e5f\u6bd4\u8f83\u7b80\u5355\u3002\u4ee5\u6211\u4eec\u7684\u6587\u7ae0\u4e3e\u4f8b\u5982\u4e0b\uff1a<\/p>\n

    \n
  • Altered serum levels of interleukin-3 in first-episode drug-naive and chronic medicated schizophrenia. Schizophrenia Research 2016; 176:196-200\u00a0<\/em><\/li>\n
  • Reduced plasma total antioxidant status in first-episode drug-naive patients with schizophrenia. Progress in Neuropsychopharmacology and Biological Psychiatry 2011\uff1b35:1064-1067<\/em><\/li>\n
  • Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics. Progress in Neuropsychopharmacology and Biological Psychiatry 2009; 33:1508-1512<\/em><\/li>\n
  • Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics. Neuroscience Letters 2009; 462:113-117<\/em><\/li>\n
  • Increased serum S100B in never-medicated and medicated schizophrenic patients.Journal of Psychiatric Research 2010; 44:1236-1240<\/em><\/li>\n
  • The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients. Schizophrenia Research 2009; 113:151-7<\/em><\/li>\n
  • Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics. Neuroscience Letters 2005; 382:27-32.\u00a0<\/em><\/li>\n
  • Decreased production of interleukin-2 (IL-2), IL-2 secreting cells and CD4+ cells in medication-free patients with schizophrenia. Journal of Psychiatric Research 2002; 36:331-336<\/em><\/li>\n
  • Altered interleukin-3 serum levels in drug-na\u00efve and neuroleptic-treated schizophrenic patients. Schizophrenia Research 2008\uff1b106:369-370<\/em>
    \n\u6709\u4e09\u7ec4\uff1a\u7cbe\u795e\u5206\u88c2\u75c7\u9996\u53d1\u7ec4+\u6162\u6027\u7ec4+\u5bf9\u7167\u7ec4<\/span><\/li>\n<\/ul>\n
    \n

    2.2. \u75c5\u4eba\u7ec4\u5206\u4e3a\u4e9a\u7ec4\uff1a<\/strong><\/span><\/p>\n<\/section>\n

    \u6bd4\u5982\u7cbe\u795e\u5206\u88c2\u75c7\u5438\u70df\u7ec4vs \u975e\u5438\u70df\u7ec4\uff0c\u81ea\u6740\u7ec4vs \u975e\u81ea\u6740\u7ec4\uff0c\u7cd6\u5c3f\u75c5\u7ec4vs \u975e\u7cd6\u5c3f\u75c5\u7ec4\u7b49\uff0c\u6bd4\u8f83\u4e9a\u7ec4\u4e4b\u95f4\u7684\u67d0\u9879\/\u4e9b\u751f\u7269\u5b66\u6307\u6807\u3002<\/p>\n

      \n
    • Reduced serum TNF alpha level in chronic schizophrenia patients with or without tardive dyskinesia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2014; 54: 259\u2013264<\/em>
      \n\u7cbe\u795e\u5206\u88c2\u75c7\u5408\u5e76TD\u5bf9\u975eTD\u4e4b\u95f4\u8840\u6e05TNF alpha\u6c34\u5e73\u5dee\u5f02<\/span><\/li>\n
    • Nicotine dependence and serum BDNF levels in male patients with schizophrenia. \u00a0Psychopharmacology 2010\uff1b212:301-307<\/em>
      \n\u7537\u6027\u7cbe\u795e\u5206\u88c2\u75c7\u5438\u70df\u7ec4\u4e0e\u975e\u5438\u70df\u7ec4\u4e4b\u95f4BDNF\u8840\u6e05\u6c34\u5e73\u5dee\u5f02<\/span><\/li>\n
    • Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics. Schizophrenia Research 2006; 81:291-300<\/em>
      \n\u4e0d\u540c\u7684\u6297\u7cbe\u795e\u75c5\u836f\u4e4b\u95f4\u5bf9\u6297\u6c27\u5316\u9176\u548c\u8102\u8d28\u8fc7\u6c27\u5316\u7269\u7684\u5dee\u5f02\u5f71\u54cd<\/span><\/li>\n
    • Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenic patients with tardive dyskinesia. Journal of Clinical Psychiatry 2007; 68:754-760<\/em>
      \n\u7cbe\u795e\u5206\u88c2\u75c7\u5408\u5e76TD\u5bf9\u6297\u6c27\u5316\u9176\u548c\u8102\u8d28\u8fc7\u6c27\u5316\u7269\u7684\u5f71\u54cd<\/span><\/li>\n
    • Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics. Psychopharmacology 2008\uff1b201: 383-389<\/em>
      \n\u7cbe\u795e\u5206\u88c2\u75c7\u5438\u70df\u8005\u7684\u7ec6\u80de \u56e0\u5b50\u8840\u6e05\u6c34\u5e73\u964d\u4f4e\uff0c\u56e0\u4e3a\u7528\u4e86\u590d\u6570\uff0c\u8bf4\u660e\u6709\u591a\u4e2a\u7ec6\u80de\u56e0\u5b50<\/span><\/li>\n
    • Nicotine dependence, symptoms and oxidative stress in male patients with schizophrenia. Neuropsychopharmacology 2007\uff1b32:2020-2024<\/em>
      \n\u7cbe\u795e\u5206\u88c2\u75c7\u5438\u70df\u5bf9\u75c7\u72b6\u548c\u6c27\u5316\u5e94\u6fc0\u6307\u6807\u7684\u5f71\u54cd\u3002\u8fd9\u7bc7\u6587\u7ae0\u80cc\u540e\u6709\u4e2a\u5f88\u7cbe\u5f69\u7684\u6545\u4e8b\uff0c\u6211\u5728\u8bb2\u8bfe\u4e2d\u63d0\u5230\u8fc7\uff0c\u5927\u5bb6\u60f3\u8d77\u6765\u4e86\u5417\uff1f<\/span><\/li>\n
    • Altered IL-2, IL-6 and IL-8 serum levels in schizophrenia patients with tardive dyskinesia. \u00a0Schizophrenia Research 2015; 162(1-3):261-268<\/em>
      \n\u7cbe\u795e\u5206\u88c2\u75c7\u5408\u5e76TD \u5bfc\u81f4\u4e09\u4e2a\u7ec6\u80de\u56e0\u5b50\u6539\u53d8\u3002\u7528\u4e86altered \u8fd9\u4e2a\u8bcd\uff0c\u800c\u4e0d\u662fhigher\/increased \u6216\u8005\u662flower\/decreased, \u8bf4\u660e\u4ec0\u4e48\u5462\uff1f \u8bf4\u660e\u6709\u9ad8\u6709\u4f4e<\/span><\/li>\n
    • Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics. Neuroscience Letters 2009\uff1b462:113-7<\/em>
      \n\u4e0e\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\u76f8\u6bd4\uff0c\u6c2f\u6c2e\u5e73\u589e\u52a0S100B\u8840\u6e05\u6c34\u5e73<\/span><\/li>\n
    • Reduced status of plasma total antioxidant capacity in schizophrenia with tardive dyskinesia. Journal of Psychiatric Research 2010\uff1b44:1111-2.<\/em><\/li>\n<\/ul>\n
      \n

      2.3. \u751f\u7269\u5b66\u6307\u6807+\u4e34\u5e8a\u75c7\u72b6\/\u8ba4\u77e5\u529f\u80fd\uff1a<\/strong><\/span><\/p>\n<\/section>\n

      \u8fd9\u7c7b\u7814\u7a76\u5728\u4e34\u5e8a\u4e0a\u4e5f\u6bd4\u8f83\u5e38\u89c1\uff0c\u5c31\u662f\u7eb3\u5165\u4e00\u7ec4\u6216\u51e0\u7ec4\u75c5\u4eba+\u6b63\u5e38\u7ec4\uff0c\u7136\u540e\u68c0\u6d4b\u67d0\u9879\/\u51e0\u9879\u751f\u7269\u5b66\u6307\u6807\uff0c\u540c\u65f6\u75c5\u4eba\u8fd8\u68c0\u6d4b\u4e86\u4e34\u5e8a\u75c7\u72b6\uff0c\u548c\/\u6216\u8005\u8ba4\u77e5\u529f\u80fd\u7b49\u3002\u7edf\u8ba1\u5206\u6790\u76f8\u5bf9\u6709\u4e9b\u590d\u6742\u3002<\/p>\n

        \n
      • Extensive white matter abnormalities and clinical symptoms in first episode and drug-na\u00efve schizophrenia: a voxel-based diffusion tensor imaging study. Journal of Clinical Psychiatry 2016;77: 205\u2013211<\/em>
        \n\u68c0\u6d4b\u9996\u53d1\u4ece\u672a\u670d\u836f\u7684\u7cbe\u795e\u5206\u88c2\u75c7DTI\uff0c\u540c\u65f6\u6d4b\u67e5PANSS\uff0c\u5206\u6790DTI\u53d8\u5316\u4e0e\u4e34\u5e8a\u75c7\u72b6\u5173\u7cfb<\/span><\/li>\n
      • Interleukin 18 and cognitive impairment in first episode and drug na\u00efve schizophrenia versus healthy controls. Brain Behavior and Immunity 2013; 32:105-111<\/em>
        \n\u9996\u53d1\u4ece\u672a\u670d\u836f\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u68c0\u6d4b\u8840IL-18\uff0c\u540c\u65f6\u68c0\u6d4bPANSS, \u5206\u6790IL-18\u4e0e\u4e34\u5e8a\u75c7\u72b6\u5173\u7cfb<\/span><\/li>\n
      • Thioredoxin, a novel oxidative stress marker and cognitive performance in chronic and medicated schizophrenia versus healthy controls. Schizophrenia Research 2013;143:301-306<\/em>
        \n\u68c0\u6d4b\u6162\u6027\u7cbe\u795e\u5206\u88c2\u75c7\u786b\u6c27\u8fd8\u86cb\u767d\uff0c\u540c\u65f6\u6d4b\u67e5\u8ba4\u77e5\u529f\u80fd, \u5206\u6790\u5b83\u4eec\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u56e0\u4e3a\u786b\u6c27\u8fd8\u86cb\u767d\u662f\u5728\u56fd\u9645\u7cbe\u795e\u79d1\u7b2c\u4e00\u6b21\u62a5\u9053\uff0c\u6bd4\u8f83\u5c11\u89c1\u7684\u4e00\u4e2a\u6297\u6c27\u5316\u86cb\u767d\uff0c\u6240\u4ee5\u5728\u9898\u76ee\u4e2d\u4e13\u95e8\u7ed9\u51fa\u8bf4\u660e<\/span><\/li>\n
      • Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia. Psychopharmacology 2012\uff1b222(2):277-284<\/em>
        \n\u6b64\u7c7b\u7814\u7a76\u7684\u5178\u578b\u9898\u76ee\uff1a\u6162\u6027\u7cbe\u795e\u5206\u88c2\u75c7BDNF\u964d\u4f4e\uff0c\u4e0e\u8ba4\u77e5\u635f\u4f24\u76f8\u5173<\/li>\n
      • Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: inverse association with positive symptoms. Progress in Neuropsychopharmacology and Biological Psychiatry 2012\uff1b36:34-38<\/em>
        \n\u6b64\u7c7b\u7814\u7a76\u7684\u5178\u578b\u9898\u76ee\uff1a\u9996\u53d1\u672a\u670d\u836f\u7cbe\u795e\u5206\u88c2\u75c7\u8840\u6d46SOD\u5347\u9ad8\uff0c\u4e0e\u9633\u6027\u75c7\u72b6\u76f8\u5173<\/span><\/li>\n
      • Decreased serum TNF-alpha levels in chronic schizophrenia patients on long-term antipsychotics: correlation with psychopathology and cognition. Psychopharmacology 2015;232:165-172<\/em>
        \n\u6b64\u7c7b\u7814\u7a76\u7684\u5178\u578b\u9898\u76ee\uff1a\u6162\u6027\u957f\u671f\u670d\u7528\u6297\u7cbe\u795e\u75c5\u836f\u7684\u7cbe\u795e\u5206\u88c2\u75c7TNF alpha \u964d\u4f4e\uff0c\u4e0e\u4e34\u5e8a\u75c7\u72b6\u548c\u8ba4\u77e5\u635f\u4f24\u76f8\u5173<\/span><\/li>\n
      • Decreased interleukin-10 serum levels in first-episode drug-na\u00efve schizophrenia: Relationship to psychopathology. Schizophrenia Research 2014;156: 9-14<\/em>
        \n\u5178\u578b\u9898\u76ee\uff1a\u9996\u53d1\u672a\u670d\u836f\u7cbe\u795e\u5206\u88c2\u75c7\u8840\u6d46IL-10\u964d\u4f4e\uff0c\u4e0e\u4e34\u5e8a\u75c7\u72b6\u76f8\u5173<\/span><\/li>\n
      • Increased interleukin-2 serum levels were associated with psychopathological symptoms and cognitive deficits in treatment-resistant schizophrenia. Schizophrenia Research 2015;169:16-21<\/em>
        \n\u5178\u578b\u9898\u76ee\uff1a\u96be\u6cbb\u6027\u7cbe\u795e\u5206\u88c2\u75c7IL-2 \u589e\u9ad8\uff0c\u4e0e\u4e34\u5e8a\u75c7\u72b6\u548c\u8ba4\u77e5\u635f\u4f24\u76f8\u5173<\/span><\/li>\n
      • Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: Association with dyskinetic movements. Journal of Psychiatric Research 2010; 44: 429\u2013433<\/em>
        \n\u7cbe\u795e\u5206\u88c2\u75c7TD\u7ec4\u7684S100B\u589e\u9ad8\uff0c\u800c\u4e14\u4e0e\u8fd0\u52a8\u969c\u788d\u75c7\u72b6\u76f8\u5173<\/span><\/li>\n
      • Low BDNF is associated with cognitive impairments in patients with Parkinson’s disease. \u00a0Parkinsonism and Related Disorders 2016; 29:66-71<\/em>
        \n\u6211\u5e26\u7684\u795e\u7ecf\u5185\u79d1\u7684\u535a\u58eb\u751f\uff0c\u6269\u5c55\u6211\u4eec\u7684\u7814\u7a76\u5230\u5e15\u91d1\u68ee\u6c0f\u75c5\uff0c\u4ece\u9898\u76ee\u770b\uff0c\u75c5\u4eba\u8840BDNF\u964d\u4f4e\uff0c\u8ba4\u77e5\u635f\u4f24\uff0c\u4e24\u8005\u5b58\u5728\u5173\u8054<\/span><\/li>\n
      • Low BDNF is associated with cognitive deficits in patients with type 2 diabetes.Psychopharmacology 2013; 227(1):93-100<\/em>
        \n\u6211\u5e26\u7684\u5185\u5206\u6ccc\u5b66\u79d1\u7684\u535a\u58eb\u751f\uff0c\u6269\u5c55\u6211\u4eec\u7684\u7814\u7a76\u5230\u7cd6\u5c3f\u75c5\uff0c\u4ece\u9898\u76ee\u770b\uff0c\u75c5\u4eba\u8840BDNF\u964d\u4f4e\uff0c\u8ba4\u77e5\u635f\u4f24\uff0c\u4e24\u8005\u5b58\u5728\u5173\u8054\u3002\u770b\u6765\u4e0d\u7ba1\u662f\u7cbe\u795e\u75be\u75c5\uff0c\u8fd8\u662f\u5185\u79d1\u75be\u75c5\uff0c\u75c5\u4ebaBDNF\u6c34\u5e73\u964d\u4f4e\u5728\u8ba4\u77e5\u529f\u80fd\u635f\u4f24\u4e2d\u8d77\u4f5c\u7528<\/span><\/li>\n
      • Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology. Schizophrenia Research 57:247-258 (2002).<\/em><\/li>\n
      • Elevated blood superoxide dismutase in neuroleptic-free schizophrenia: association with positive symptoms. Psychiatry Research 117:85-88 (2003).<\/li>\n
      • Decreased levels of serum brain-derived neurotrophic factor in drug-na\u00efve first-episode schizophrenia: relationship to clinical phenotypes. Psychopharmacology 207:375-80 (2009)<\/em><\/li>\n<\/ul>\n
        \n

        2.4.\u00a0\u75c5\u4eba\u7ec4vs\u6b63\u5e38\u7ec4\uff1a\u5355\u4e2a\u6216\u591a\u4e2a\u57fa\u56e0\u578b+\u4e34\u5e8a\u75c7\u72b6\/\u8ba4\u77e5\u529f\u80fd\uff1a<\/strong><\/span><\/p>\n<\/section>\n

        \u7cbe\u795e\u75be\u75c5\u7684\u9057\u4f20\u5b66\u7814\u7a76\u662f\u7814\u7a76\u70ed\u70b9\uff0c\u4f46\u968f\u7740GWAS\u7b49\u6280\u672f\u7684\u53d1\u5c55\uff0c\u73b0\u5728\u5355\u7eaf\u7684case-control\u7814\u7a76\u5f88\u96be\u53d1\u8868\u6587\u7ae0\u4e86\uff0c\u4f46\u4e0e\u4e34\u5e8a\u75c7\u72b6\u3001\u8ba4\u77e5\u529f\u80fd\u4ee5\u53ca\u4e00\u4e9b\u4e9a\u578b\u7ed3\u5408\uff0c\u8fd8\u80fd\u53d1\u8868\u6587\u7ae0\uff0c\u5c24\u5176\u662f\u80fd\u627e\u5230\u4e00\u4e9b\u597d\u7684endophenotype \u5185\u8868\u578b\uff0c\u80fd\u53d1\u5f88\u597d\u6587\u7ae0\u3002\u53e6\u5916\u5982\u679c\u540c\u65f6\u68c0\u6d4b\u4e862\u4e2a\u4ee5\u4e0a\u7684\u57fa\u56e0\u591a\u6001\u6027\uff0c\u9700\u8981\u7279\u522b\u7684\u9057\u4f20\u7edf\u8ba1\u8f6f\u4ef6\uff0c\u505ahaplotype\u5206\u6790\u3002<\/p>\n

          \n
        • The CCK-A receptor gene possibly associated with positive symptoms of schizophrenia. Molecular Psychiatry 2000\uff1b5:239-240<\/em>
          \n\u8fd9\u662f\u6211\u7684\u7b2c\u4e00\u7bc7SCI\u6587\u7ae0\uff0c\u5f88\u4e45\u4ee5\u524d\u53d1\u8868\u7684\uff0c\u5728\u82f1\u56fd\u7684\u851a\u519b\u8001\u5e08\u6307\u5bfc\u548c\u5e2e\u52a9\u4e0b\u53d1\u8868\uff0c\u53d1\u73b0CCK\u53d7\u4f53\u57fa\u56e0\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u9633\u6027\u75c7\u72b6\u76f8\u5173<\/span><\/li>\n
        • Tumour necrosis factor alpha polymorphism (-1031T\/C) is associated with age of onset of schizophrenia. Molecular Psychiatry 2005; 10:897-899<\/em>
          \nTNF alpha \u7684\u8fd9\u4e2a\u591a\u6001\u6027\u4e0e\u53d1\u75c5\u5e74\u9f84\u6709\u5173<\/span><\/li>\n
        • BDNF polymorphisms are associated with schizophrenia onset and positive symptoms.Schizophrenia Research 2016; 170:41-47<\/em>
          \nBDNF\u591a\u6001\u6027\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u53d1\u75c5\u548c\u9633\u6027\u75c7\u72b6\u76f8\u5173\uff0c\u6ce8\u610f\uff1apolymorphisms\u591a\u6001\u6027\u7528\u4e86\u590d\u6570\uff0c\u8bf4\u660e\u4e0d\u6b62\u4e00\u4e2a, \u7edf\u8ba1\u65b9\u6cd5\u4e5f\u4e0d\u4e00\u6837\u4e86<\/span><\/li>\n
        • BDNF polymorphisms are associated with cognitive performance in schizophrenia versus healthy controls. Journal of Clinical Psychiatry 2016; 77(8):e1011-e1018<\/em>
          \nBDNF\u591a\u6001\u6027\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u8ba4\u77e5\u529f\u80fd\u76f8\u5173\u3002<\/span>\u5927\u5bb6\u770b\u5230\u4e86\u5427\uff0c\u4e0e\u4e0a\u4e2a\u9898\u76ee\u5f88\u50cf\uff0c\u5927\u5bb6\u8fd8\u8bb0\u5f97\u6211\u5728\u516c\u4f17\u53f7\u91cc\u66fe\u7ecf\u5199\u7684\u4e00\u7bc7\u6587\u7ae0\u91cc\u63d0\u5230\u4e00\u4e2a\u9006\u88ad\u7684\u6545\u4e8b\u5417\uff1f\u3002\u672c\u6765\u8fd9\u4e24\u7bc7\u6587\u7ae0\u7684\u5185\u5bb9\u662f\u653e\u5728\u4e00\u7bc7\u6587\u7ae0\u91cc\uff0c\u6295\u7a3fPsychoneuroendocrinology\uff0cIF=4.7\uff0c\u5df2\u7ecf\u88ab\u8981\u6c42\u4fee\u56de\u4e86\uff0c\u6211\u4ee5\u4e3a\u4fee\u7a3f\u540e\u5e94\u8be5\u80fd\u987a\u5229\u88ab\u63a5\u53d7\u7684\uff0c\u4f46\u672a\u66fe\u60f3\u6700\u540e\u7adf\u7136\u88ab\u62d2\u7a3f\u4e86\uff0c\u53cd\u590d\u601d\u8003\u540e\uff0c\u51b3\u5b9a\u62c6\u5206\u4e3a\u8fd9\u4e24\u7bc7\uff0c\u6700\u540e\u90fd\u88ab\u63a5\u53d7\u4e86\uff0cJCP \u7684IF=5.5\uff0cSR \u7684IF=4.5\uff0c\u5f71\u54cd\u56e0\u5b50\u603b\u5206\u589e\u52a0\u4e00\u500d\u591a\uff0c\u9006\u88ad\u6210\u529f\u3002<\/li>\n<\/ul>\n

          \u672a\u5b8c\u5f85\u7eed\u2026\u2026<\/strong><\/p>\n

          \u4e0b\u4e00\u7bc7\u6587\u7ae0\uff08\u7b2c\u4e09\u7bc7\uff09\u5c06\u4ece\uff1a<\/strong><\/p>\n

          \u4e09\uff0c\u7cfb\u7edf\u4e4b\u95f4\u7684\u4ea4\u4e92\u4f5c\u7528<\/p>\n

          \u56db\uff0c\u6cbb\u7597\u524d\u540e\u4e34\u5e8a\u7597\u6548+\u751f\u7269\u5b66\u6307\u6807<\/p>\n

          \u7b49\u591a\u4e2a\u65b9\u9762\uff0c\u7ee7\u7eed\u8be6\u7ec6\u4ecb\u7ecd\u5982\u4f55\u5199\u4e00\u4e2a\u597d\u7684\u9898\u76ee\uff0c\u4ee5\u53ca\u66f4\u591a\u7684\u79d1\u7814\u601d\u8def\u3002<\/p>\n

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          <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
          \n

          \u6ce8\uff1a\u672c\u6587\u662f\u7ee7\u4e0a\u7bc7\u7531\u5f20\u5411\u9633\u6559\u6388\u64b0\u5199\u7684\u300a\u6295\u7a3fSCI\u8bba\u6587\uff0c\u5982\u4f55\u5199\u4e00\u4e2a\u5438\u5f15\u4eba\u7684\u9898\u76ee+\u79d1\u7814\u601d\u8def\u300b\u7684\u7b2c\u4e8c\u7bc7\uff0c\u4e3b\u8981\u8c08\u5bf9\u4e8e\u5305\u542b\u751f\u7269\u5b66\u6307\u6807\u7684\u6587\u7ae0\uff0c\u5982\u4f55\u53bb\u5199\u4e00\u4e2a\u5438\u5f15\u4eba\u7684\u6807\u9898\uff0c\u540c\u65f6\u5982\u4f55\u5229\u7528\u751f\u7269\u5b66\u6307\u6807\uff0c\u7ed3\u5408\u4e34\u5e8a\u8d44\u6599\u53bb\u505a\u79d1\u7814\u3002<\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

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