{"id":64,"date":"2017-02-17T12:07:24","date_gmt":"2017-02-17T04:07:24","guid":{"rendered":"http:\/\/www.ithenticate.com.cn\/news\/?p=64"},"modified":"2017-02-17T12:07:24","modified_gmt":"2017-02-17T04:07:24","slug":"%e6%8a%95%e7%a8%bfsci%e8%ae%ba%e6%96%87%ef%bc%8c%e5%a6%82%e4%bd%95%e5%86%99%e4%b8%80%e4%b8%aa%e5%90%b8%e5%bc%95%e4%ba%ba%e7%9a%84%e9%a2%98%e7%9b%ae%e7%a7%91%e7%a0%94%e6%80%9d%e8%b7%af","status":"publish","type":"post","link":"https:\/\/www.ithenticate.com.cn\/news\/?p=64","title":{"rendered":"\u6295\u7a3fSCI\u8bba\u6587\uff0c\u5982\u4f55\u5199\u4e00\u4e2a\u5438\u5f15\u4eba\u7684\u9898\u76ee+\u79d1\u7814\u601d\u8def"},"content":{"rendered":"<p>\u6211\u4eec\u6295\u7a3f\u65f6\uff0c\u4e3b\u7f16\u4ee5\u53ca\u5ba1\u7a3f\u8005\u9996\u5148\u770b\u5230\u7684\u5c31\u662f\u9898\u76ee\uff0c\u56e0\u6b64\u4e00\u4e2a\u5438\u5f15\u4eba\u7684\u9898\u76ee\u81f3\u5173\u91cd\u8981\uff0c\u751a\u81f3\u8d77\u7740\u753b\u9f99\u70b9\u775b\u7684\u6548\u679c\u3002\u4ee5\u524d\u6211\u6709\u4e2a\u4e60\u60ef\uff0c\u5728pubmed.com\u627e\u5230\u76f8\u5173\u6587\u732e\uff0c\u7136\u540e\u628a\u6458\u8981\u6253\u5370\u51fa\u6765\u53bb\u770b\uff0c\u540e\u6765\u9010\u6e10\u517b\u6210\u4e86\u65b0\u7684\u4e60\u60ef\uff1a\u5c31\u662f\u8f93\u5165\u5173\u952e\u8bcd\uff0c\u7136\u540e\u628a\u76f8\u5173\u6587\u732e\u7684\u9898\u76ee\u6253\u5370\u51fa\u6765\uff0c\u53cd\u590d\u770b\u3001\u53cd\u590d\u7422\u78e8\uff0c\u6162\u6162\u5730\u5f88\u591a\u65b0\u7684\u601d\u8def\u5c31\u51fa\u6765\u4e86\u3002\u8fd9\u8bf4\u660e\u4ece\u9898\u76ee\u4e2d\u80fd\u770b\u51fa\u5f88\u591a\u4fe1\u606f\u51fa\u6765\u3002<\/p>\n<p>\u5199\u4e00\u4e2a\u597d\u7684\u9898\u76ee\u9700\u8981\u53cd\u590d\u7422\u78e8\u3001\u53cd\u590d\u63a8\u6572\uff0c\u6211\u4e66\u5199\u6587\u7ae0\u65f6\uff0c\u4e00\u822c\u662f\u5148\u5199\u4e00\u4e2a\u9898\u76ee\u4e0b\u6765\uff0c\u7136\u540e\u53bb\u5199\u6587\u7ae0\u5176\u5b83\u90e8\u5206\uff0c\u7b49\u5168\u6587\u5b8c\u6210\u540e\uff0c\u6839\u636e\u7ed3\u679c\u548c\u4e3b\u8981\u7814\u7a76\u53d1\u73b0\uff0c\u518d\u56de\u5934\u53cd\u590d\u4fee\u6539\u9898\u76ee\u3002\u82f1\u6587\u7684\u8bba\u6587\u9898\u76ee\u4e0d\u540c\u4e8e\u4e2d\u6587\uff0c\u4ece\u82f1\u8bed\u9898\u76ee\u4e2d\u4e0d\u4f46\u80fd\u5224\u65ad\u4e00\u7bc7\u6587\u7ae0\u7684\u7814\u7a76\u5185\u5bb9\uff0c\u66f4\u91cd\u8981\u7684\u662f\u8fd9\u7bc7\u6587\u7ae0\u7684\u4e3b\u8981\u53d1\u73b0\u4e5f\u4f53\u73b0\u5728\u9898\u76ee\u4e2d\uff0c\u751a\u81f3\u4e00\u4e2a\u5c0f\u7ec6\u8282\u90fd\u6697\u542b\u7684\u610f\u4e49\u4e0d\u540c\u3002\u6bd4\u5982\u505a\u9057\u4f20\u5b66\u7814\u7a76\u65f6\uff0c\u9898\u76ee\u4e2d\u4f1a\u51fa\u73b0\u8fd9\u6837\u7684\u8868\u8ff0\uff1a gene polymorphism, \u00a0\u770b\u5230\u8fd9\u6211\u4eec\u5c31\u77e5\u9053\uff0c\u672c\u6587\u7814\u7a76\u67d0\u4e2a\u57fa\u56e0\u578b\u7684\u5355\u4e2a\u591a\u6001\u6027\uff0c\u91c7\u7528\u6bd4\u8f83\u7b80\u5355\u7684\u7edf\u8ba1\u65b9\u6cd5\u3002\u4f46\u5982\u679c\u591a\u52a0\u4e00\u4e2as\uff0cpolymorphisms\uff0c\u90a3\u4e48\u8bf4\u660e\u672c\u6587\u68c0\u6d4b\u4e86\u591a\u4e2a\u591a\u6001\u6027\uff0c\u5e94\u8be5\u6709\u591a\u500d\u578bhaplotype \u5206\u6790\uff0c\u91c7\u7528\u7684\u9057\u4f20\u7edf\u8ba1\u65b9\u6cd5\u5f88\u4e0d\u540c\u4e86\u3002<\/p>\n<p>\u4e3e\u4e2a\u4f8b\u5b50\uff0c\u6211\u6b63\u5728\u4fee\u6539\u7684\u4e00\u7bc7\u6587\u7ae0\uff0c\u9898\u76ee\u662f\u201c<strong>Genetic association of CRHR1, FKBP5, and BDNF with depression in a Chinese population<\/strong>\u201d\uff0c \u8fd9\u4e2a\u9898\u76ee\u770b\u8d77\u6765\u4e0d\u9519\uff0c\u4f46\u6211\u770b\u5b8c\u6587\u7ae0\u540e\uff0c\u6539\u4e3a \u201c<strong>Genetic polymorphisms of FKBP5 and BDNF but not CRHR1 genes are associated with job-related depression in a Chinese Han population<\/strong>\u201d\uff0c\u5927\u5bb6\u591a\u770b\u51e0\u904d\uff0c\u4ed4\u7ec6\u7422\u78e8\u7422\u78e8\uff0c\u662f\u4e0d\u662f\u7b2c\u4e8c\u4e2a\u9898\u76ee\u66f4\u660e\u786e\uff0c\u66f4\u7a81\u51fa\u9633\u6027\u7ed3\u679c\uff0c\u6709\u8fd9\u4e48\u51e0\u4e2a\u6539\u52a8\uff1a<\/p>\n<p><span style=\"color: #3366ff;\">1\u3001depression \u6539\u4e3ajob-related depression, \u00a0\u8fd9\u4e48\u4e00\u6539\u52a8\uff0c\u6574\u4e2a\u7814\u7a76\u5c31\u663e\u5f97\u4e0d\u540c\u51e1\u54cd\u4e86\uff0c\u4e3a\u4ec0\u4e48\u8fd9\u4e48\u8bf4\u5462\uff1f \u56e0\u4e3adepression \u5f88\u666e\u901a\uff0c\u592a\u591a\u7684\u7814\u7a76\u62a5\u9053\u4e86\uff0c\u800c\u5bf9job-related \u57fa\u56e0\u578b\u7814\u7a76\u975e\u5e38\u5c11\uff0c\u5bf9\u4e09\u4e2a\u57fa\u56e0\u7684\u7814\u7a76\u5c1a\u65e0\u62a5\u9053\uff0c\u4e00\u4e0b\u5b50\u5c31\u7a81\u51fa\u4e86novelty\u3002<\/span><\/p>\n<p><span style=\"color: #3366ff;\">2\u3001\u7b2c\u4e00\u4e2a\u9898\u76ee\u7ed9\u4eba\u7684\u611f\u89c9\u662fCRHR1\u4e5f\u4e0edepression\u76f8\u5173, \u4f46\u5b9e\u9645\u7ed3\u679c\u662f\u65e0\u76f8\u5173\uff0c\u6240\u4ee5\u6539\u4e3aFKBP5 and BDNF but not CRHR1\u3002<\/span><\/p>\n<p><span style=\"color: #3366ff;\">3\u3001\u589e\u52a0\u4e86 Han\uff0c\u66f4\u660e\u786e\u3002<\/span><\/p>\n<p><strong>\u8bf7\u5927\u5bb6\u5728\u770b\u4e0b\u9762\u7684\u9898\u76ee\u4ecb\u7ecd\u8fc7\u7a0b\u4e2d\uff0c\u591a\u53bb\u601d\u8003\uff0c\u7ed3\u5408\u81ea\u5df1\u7684\u8bfe\u9898\u770b\u770b\u5982\u4f55\u53bb\u5199\u9898\u76ee\u3002\u5b9e\u9645\u4e0a\u6b63\u5982\u6211\u4e0a\u9762\u6240\u8bf4\uff0c\u770b\u9898\u76ee\u672c\u8eab\u5c31\u80fd\u542f\u53d1\u601d\u8def\u4e0b\u9762\u6839\u636e\u6211\u4eec\u81ea\u5df1\u7684\u6587\u7ae0\u4e3e\u4f8b\uff0c\u4e0b\u9762\u6765\u8bf4\u660e\u600e\u4e48\u53bb\u5199\u4e00\u4e2a\u597d\u7684\u9898\u76ee\uff1a<\/strong><\/p>\n<section class=\"\">\n<section class=\"\"><strong><span class=\"\"> \u00a0 \u00a0\u4e00\uff0c\u5355\u7eaf\u7684\u4e34\u5e8a\u7814\u7a76 \u00a0 \u00a0<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<section>\n<section class=\"\">\n<section class=\"\">\n<p class=\"\"><strong>1.1. \u5c0f\u89c4\u6a21\u7684\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\uff1a<\/strong><\/p>\n<\/section>\n<\/section>\n<p>\u4e00\u822c\u60c5\u51b5\u662f\u5c0f\u7684\u6d41\u884c\u75c5\u5b66\u8c03\u67e5\uff0c\u6bd4\u5982\u7cbe\u795e\u5206\u88c2\u75c7\u4e2d\u7684\u5438\u70df\u3001\u7cd6\u5c3f\u75c5\u3001\u81ea\u6740\u7b49\u60c5\u51b5\uff0c\u8fd9\u91cc\u9762\u7275\u6d89\u5230\u4e00\u4e2a\u53d1\u75c5\u7387\u548c\u76f8\u5173\u7684\u5371\u9669\u56e0\u7d20\uff0c\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u9700\u8981\u7a81\u51faprevalence, clinical correlates\u548crisk factors \u7b49\uff0c\u6211\u4eec\u7684\u51e0\u7bc7\u6587\u7ae0\u9898\u76ee\u5982\u4e0b\uff1a<\/p>\n<p>1\u3001Cigarette smoking in male patients with chronic schizophrenia in a Chinese population: prevalence and relationship to clinical phenotypes.\uff08PLoS One 2012;7:e30937\uff09<\/p>\n<p><span style=\"color: #3366ff;\">\u4ece\u9898\u76ee\u4e2d\u53ef\u4ee5\u770b\u51fa\u672c\u6587\u8c03\u67e5\u4e86\u4e2d\u56fd\u4eba\u7fa4\u4e2d\u7537\u6027\u3001\u6162\u6027\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u5438\u70df\u7387\u548c\u76f8\u5173\u7684\u4e34\u5e8a\u6307\u6807\uff0c\u8fd9\u4e9b\u6307\u6807\u53c8\u5305\u62ec\u4e86\u4eba\u53e3\u5b66\u8d44\u6599\u548c\u4e34\u5e8a\u75c7\u72b6\u3002<\/span><\/p>\n<p>2\u3001Prevalence, demographic and clinical correlates of suicide attempts in Chinese medicated chronic inpatients with schizophrenia. \uff08J Psychiatr Res 2013; 47:1370-1375\uff1b\uff09<\/p>\n<p><span style=\"color: #3366ff;\">\u8fd9\u4e2a\u662f\u6b64\u7c7b\u6587\u7ae0\u7684\u7ecf\u5178\u9898\u76ee\uff0c\u5305\u62ec\u4e86prevalence, demographic and clinical correlates\u3002<\/span><\/p>\n<p>3\u3001The prevalence, risk factors and clinical correlates of obesity in Chinese patients with schizophrenia. \uff08Psychiatry Research 2016\uff09<\/p>\n<p><span style=\"color: #3366ff;\">\u4e5f\u662f\u6b64\u7c7b\u6587\u7ae0\u7684\u7ecf\u5178\u9898\u76ee\u3002<\/span><\/p>\n<p>\u7c7b\u4f3c\u7684\u9898\u76ee\u5982\u4e0b\uff0c\u5927\u5bb6\u5199\u6b64\u7c7b\u4e34\u5e8a\u8c03\u67e5\u7684\u6587\u7ae0\u65f6\uff0c\u53ef\u4ee5\u6a21\u4eff\u8fd9\u4e9b\u9898\u76ee\uff1a<\/p>\n<ul class=\"list-paddingleft-2\">\n<li>The prevalence and clinical-demographic correlates of diabetes mellitus in chronic schizophrenic patients receiving clozapine. (Hum Psychopharmacol 2011; 26:392-296)<\/li>\n<li>Prevalence of tardive dyskinesia in chronic male inpatients with schizophrenia on long-term clozapine versus typical antipsychotics. (Int Clin Psychopharmacol 2014;29:318-321)<\/li>\n<\/ul>\n<p>\u53e6\u5916\uff0c\u50cf\u6211\u5728\u8bb2\u8bfe\u65f6\u5e38\u5e38\u8c08\u5230\u7684\u4e00\u5927\u65b9\u9762\uff1a\u201c<strong>\u7537\u5973\u6027\u522b\u5dee\u5f02<\/strong>\u201d\uff0c\u5728\u524d\u9762\u7684\u57fa\u7840\u4e0a\uff0c\u5728\u52a0\u4e0agender difference \u6216\u8005\u662fsex difference\uff0c\u4e3e\u4f8b\u5982\u4e0b\uff1a<\/p>\n<ul class=\"list-paddingleft-2\">\n<li>Sex difference in the prevalence of smoking in Chinese schizophrenia (J Psychiatr Res 2010;44: 986-988)<\/li>\n<li>Gender differences in the prevalence of diabetes mellitus in chronic hospitalized patients with schizophrenia on long-term antipsychotics (Psychiatry Res 2011;186:451-453)<\/li>\n<li>Gender differences in the prevalence, risk and clinical correlates of tardive dyskinesia in Chinese schizophrenia (Psychopharmacology 2009; 205: 647-654)<\/li>\n<li>Gender differences in socio-demographic and clinical characteristics of methamphetamine inpatients in a Chinese population (Drug Alcohol Depend 2013;130:94-100)<\/li>\n<li>Sex differences in body mass index and obesity in Chinese patients with chronic schizophrenia. (Journal of Clinical Psychopharmacology 2016; 36: 643-648)<\/li>\n<\/ul>\n<section class=\"\">\n<p class=\"\"><strong>1.2. \u4e34\u5e8a\u75c7\u72b6\u548c\u8ba4\u77e5\u68c0\u6d4b\uff1a<\/strong><\/p>\n<\/section>\n<p>\u6211\u4eec\u5e38\u5e38\u5728\u4e34\u5e8a\u4e0a\u91c7\u7528\u4e00\u4e9b\u91cf\u8868\uff08\u5305\u62ec\u4e34\u5e8a\u91cf\u8868\u548c\u8ba4\u77e5\u91cf\u8868\uff09\u53bb\u6d4b\u67e5\u75c5\u4eba\uff0c\u7136\u540e\u5206\u6790\u67d0\u79cd\u4e9a\u578b\uff0c\u6bd4\u5982\u80a5\u80d6\u3001\u7cd6\u5c3f\u75c5\u4e0e\u4e34\u5e8a\u75c7\u72b6\u4e0e\u8ba4\u77e5\u529f\u80fd\u7684\u5173\u8054\uff0c\u76f8\u5e94\u7684\u9898\u76ee\u5982\u4e0b\uff1a<\/p>\n<ul class=\"list-paddingleft-2\">\n<li>Obesity correlates with fewer symptoms in schizophrenia treated with long-term clozapine: gender difference (Psychiatry Res 2015; 225: 741-742)<br \/>\n<span style=\"color: #3366ff;\">\u4ece\u9898\u76ee\u4e2d\u53ef\u4ee5\u770b\u51fa\uff0c\u672c\u6587\u6211\u4eec\u53d1\u73b0\u80a5\u80d6\u75c5\u4eba\u7684\u4e34\u5e8a\u75c7\u72b6\u8f83\u8f7b\uff0c\u800c\u4e14\u9898\u76ee\u4e5f\u8868\u660e\u4e86\u662f\u5728\u957f\u671f\u670d\u7528\u6c2f\u6c2e\u5e73\u7684\u75c5\u4eba\uff0c\u5e76\u5b58\u5728\u6027\u522b\u5dee\u5f02\u3002<\/span><\/li>\n<li>Socio-demographic and clinical characteristics of heavy and non-heavy smokers among schizophrenia inpatients in a Chinese Han population (Psychopharmacology 2014; 231: 305-314)<br \/>\n<span style=\"color: #3366ff;\">\u4ece\u9898\u76ee\u4e2d\u5206\u6790\uff0c\u672c\u6587\u68c0\u6d4b\u4e86\u7cbe\u795e\u5206\u88c2\u75c7\u4f4f\u9662\u75c5\u4eba\u91cd\u6027\u5438\u70df\u8005\u7684\u4eba\u53e3\u5b66\u8d44\u6599\u548c\u4e34\u5e8a\u75c7\u72b6\u5b58\u5728\u5dee\u5f02\u3002<\/span><\/li>\n<\/ul>\n<p>\u4e0b\u9762\u662f\u5404\u79cd\u7cbe\u795e\u5206\u88c2\u75c7\u4e34\u5e8a\u4e9a\u578b\u5b58\u5728\u8ba4\u77e5\u529f\u80fd\u5dee\u5f02\uff1a<\/p>\n<ul class=\"list-paddingleft-2\">\n<li>Cigarette smoking, psychopathology, and cognitive function in first-episode drug na\u00efve schizophrenia: a case-control study (Psychological Medicine 2013; 43:1651-1660).<br \/>\n<span style=\"color: #3366ff;\">\u8fd9\u6837\u7684\u4e34\u5e8a\u91cf\u8868\u68c0\u6d4b\u7814\u7a76\uff0c\u56e0\u4e3a\u7275\u6d89\u7684\u9879\u76ee\u5f88\u591a\uff0c\u5176\u4e2d\u76f8\u4e92\u5173\u8054\u7684\u56e0\u7d20\u5f88\u591a\uff0c\u6240\u4ee5\u4e0d\u80fd\u7ed9\u51fa\u7814\u7a76\u7ed3\u679c\uff0c\u53ea\u628a\u4e3b\u8981\u7684\u8c03\u67e5\u9879\u76ee\u7f57\u5217\u51fa\u6765\u5373\u53ef\u3002<\/span><\/li>\n<li>Cognitive differences in schizophrenia on long-term treatments with clozapine, risperidone and typical antipsychotics (Int Clin Psychopharmacol 2015; 30:89-95).<br \/>\n<span style=\"color: #3366ff;\">\u4ece\u9898\u76ee\u4e2d\u770b\u51fa\uff0c\u4e0d\u540c\u6297\u7cbe\u795e\u75c5\u836f\u4e4b\u95f4\u5bf9\u8ba4\u77e5\u529f\u80fd\u7684\u5f71\u54cd\u5b58\u5728\u5dee\u5f02\u3002<\/span><\/li>\n<li>Cognitive function and suicide risk in Han Chinese inpatients with schizophrenia (Psychiatry Res 2014; 220:188-192)<br \/>\n<span style=\"color: #3366ff;\">\u6c49\u65cf\u4f4f\u9662\u7cbe\u795e\u5206\u88c2\u75c7\u4e2d\u6709\u65e0\u81ea\u6740\u53f2\u5b58\u5728\u8ba4\u77e5\u529f\u80fd\u5dee\u5f02\u3002<\/span><\/li>\n<li>Diabetes and cognitive deficits in chronic schizophrenia: a case-control study (PLoS One 2013;8:e66299;)<br \/>\n<span style=\"color: #3366ff;\">\u7cbe\u795e\u5206\u88c2\u75c7\u5408\u5e76\u7cd6\u5c3f\u75c5\u6709\u8ba4\u77e5\u529f\u80fd\u5f02\u5e38\uff0c\u9898\u76ee\u4e2d\u6709case-control, \u8bf4\u660e\u672c\u6587\u6709\u4e00\u7ec4\u6b63\u5e38\u7ec4\u3002<\/span><\/li>\n<li>Tardive dyskinesia is associated with greater cognitive impairment in schizophrenia (Prog Neuropsychopharmacol Biol Psychiatry 2013; 46:71-77.)<br \/>\n<span style=\"color: #3366ff;\">\u7cbe\u795e\u5206\u88c2\u75c7\u5408\u5e76\u8fdf\u53d1\u6027\u8fd0\u52a8\u969c\u788d\u5b58\u5728\u8ba4\u77e5\u529f\u80fd\u5f02\u5e38\u3002<\/span><\/li>\n<li>Cognitive impairments in first-episode drug-naive and chronic medicated schizophrenia: MATRICS consensus cognitive battery in a Chinese Han population (Psychiatry Res 2016; 238:196-202;)<br \/>\n<span style=\"color: #3366ff;\">\u540c\u65f6\u5728\u9996\u53d1\u3001\u6162\u6027\u7cbe\u795e\u5206\u88c2\u75c7\u75c5\u4eba\u4e2d\u68c0\u6d4b\u4e86\u8ba4\u77e5\u529f\u80fd\uff0c\u5e76\u7a81\u51fa\u5e94\u7528\u4e86MATRICS\u8fd9\u4e2a\u68c0\u6d4b\u5de5\u5177\u3002<\/span><\/li>\n<\/ul>\n<section class=\"\">\n<p class=\"\"><strong>1.3. Clinical trial\u6cbb\u7597\u524d\u540e\uff1a<\/strong><\/p>\n<\/section>\n<p>\u5728\u4e34\u5e8a\u6211\u4eec\u5e38\u5e38\u505a\u53cc\u76f2\u3001\u7a7a\u767d\u5bf9\u7167\u7814\u7a76\uff0c\u6709\u65f6\u53c8\u91c7\u7528\u4e86\u500d\u589e\u7684\u836f\u7269\u5242\u91cf\uff0c\u8fd9\u6837\u60c5\u51b5\u4e0b\u5982\u4f55\u4e66\u5199\u4e00\u4e2a\u597d\u7684\u9898\u76ee\u5462\uff1f<\/p>\n<p>\u8bf7\u53c2\u8003\u4e0b\u9762\u6211\u4eec\u7684\u6587\u7ae0\u9898\u76ee\u3002\u8bf7\u6ce8\u610f\uff1a\u4e00\u5b9a\u8981\u8868\u793a\u51farandomized\uff0cdouble-blind\uff0cplacebo-controlled\uff0c\u5076\u5c14\u60c5\u51b5\u4e0b\u7a81\u51fa dose-response\u3002<\/p>\n<ul class=\"list-paddingleft-2\">\n<li>Extract of Ginkgo biloba treatment for tardive dyskinesia in schizophrenia: a randomized, double-blind, placebo-controlled trial. (J Clin Psychiatry 2011; 72:615-621)<\/li>\n<li>Adjunctive aripiprazole in the treatment of risperidone-induced hyperprolactinemia: A randomized, double-blind, placebo-controlled, dose-response study. (Psychoneuroendocrinology 2015; 58:130-140)<\/li>\n<li>A double-blind, placebo-controlled trial of extract of Ginkgo biloba added to haloperidol in treatment-resistant patients with schizophrenia. (Journal of Clinical Psychiatry 2001; 62:878-883)<\/li>\n<li>Risperidone versus haloperidol in the treatment of acute exacerbations of chronic inpatients with schizophrenia: a randomized double-blind study. (International Clinical Psychopharmacology 2001 ; 16:325-330).<\/li>\n<\/ul>\n<p><strong>\u8bf4\u660e\uff1a<\/strong>Clinical trial \u7814\u7a76\u662f\u5bb9\u6613\u53d1\u8868\u9ad8\u5206\u7684\u6587\u7ae0\uff0c\u56e0\u4e3a\u5b9e\u65bd\u4e34\u5e8a\u836f\u7406\u5b66\u7814\u7a76\u5f88\u56f0\u96be\uff0c\u5c24\u5176\u662f\u5728\u56fd\u5916\uff0c\u6240\u4ee5\u53ea\u8981\u91c7\u7528\u7684\u836f\u7269\u6216\u65b0\u7684\u6cbb\u7597\u624b\u6bb5\u6bd4\u8f83\u65b0\uff0c\u6709\u65b0\u7684\u53d1\u73b0\u6216\u597d\u7ed3\u679c\uff0c\u57fa\u672c\u4e0a\u80fd\u53d1\u8868\u9ad8\u5206\u6587\u7ae0\u3002\u8fd9\u662f\u56fd\u5185\u7cbe\u795e\u79d1\u7684\u4f18\u52bf\uff0c\u5982\u679c\u60f3\u53d1\u9ad8\u5206\u6587\u7ae0\u7684\u8bdd\uff0c\u8fd9\u662f\u4e00\u4e2a\u597d\u7684\u7814\u7a76\u65b9\u5411\uff0c\u5c24\u5176\u662f\u56fd\u5185\u73b0\u5728\u5f00\u59cb\u5bf9\u4e34\u5e8a\u7814\u7a76\u5f00\u59cb\u91cd\u89c6\u8d77\u6765\u3002<\/p>\n<p>\u5927\u5bb6\u6ce8\u610f\u5230\u6ca1\u6709\uff0c\u4e0a\u9762\u8fd9\u4e9b\u9898\u76ee\/\u6587\u7ae0\u5168\u90e8\u6765\u81ea\u7eaf\u4e34\u5e8a\u8d44\u6599\uff0c\u6ca1\u6709\u7528\u4efb\u4f55\u751f\u7269\u5b66\u6307\u6807\uff0c\u6240\u4ee5\u8bf4\u7cbe\u795e\u79d1\u4e34\u5e8a\u79d1\u7814\u975e\u5e38\u91cd\u8981\uff0c\u4e34\u5e8a\u8d44\u6e90\u662f\u6211\u4eec\u56fd\u5185\u7cbe\u795e\u533b\u5b66\u754c\u6700\u5927\u7684\u4f18\u52bf\u4e86\uff0c\u5982\u679c\u80fd\u8bbe\u8ba1\u51fa\u597d\u7684\u8bfe\u9898\u3001\u5145\u5206\u5229\u7528\u8d77\u4e30\u5bcc\u7684\u4e34\u5e8a\u8d44\u6e90\uff0c\u80af\u5b9a\u53ef\u4ee5\u505a\u51fa\u975e\u5e38\u7cbe\u5f69\u7684\u8bfe\u9898\u51fa\u6765\u3002\u800c\u4e14\u6700\u4e3a\u5173\u952e\u7684\u4e00\u70b9\uff1a\u505a\u4e34\u5e8a\u79d1\u7814\uff0c\u53ef\u4ee5\u4e0d\u7528\u82b1\u94b1\u3002\u8fd9\u5bf9\u6ca1\u6709\u4efb\u4f55\u79d1\u7814\u7ecf\u8d39\u7684\u5e74\u8f7b\u5b66\u8005\u548c\u533b\u751f\u62a4\u58eb\u4eec\u975e\u5e38\u6709\u5229\uff0c\u4ec5\u4ec5\u662f\u5229\u7528\u75c5\u5386\u3001\u6216\u8005\u662f\u6536\u96c6\u4e00\u4e9b\u91cf\u8868\u8d44\u6599\uff0c\u5c31\u53ef\u4ee5\u505a\u51fa\u5f88\u68d2\u7684\u8bfe\u9898\u3001\u53d1\u8868\u7cfb\u5217\u9ad8\u6c34\u5e73SCI\u6587\u7ae0\u3002<\/p>\n<p><strong>\u5728\u4e0b\u4e00\u7bc7\u6587\u7ae0\u4e2d\uff0c\u5c06\u6709\u5f20\u5411\u9633\u6559\u6388\u548c\u9879\u7389\u6d9b\u6559\u6388\u5173\u4e8e\u4e34\u5e8a\u79d1\u7814\u7684\u5bf9\u8bdd\u3002<\/strong><\/p>\n<p><strong>\u672a\u5b8c\u5f85\u7eed\u2026\u2026<\/strong><\/p>\n<p>\u4e0b\u4e00\u7bc7\u6587\u7ae0\u5c06\u4ece\uff1a<\/p>\n<p>\u4e8c\uff0c\u751f\u7269\u5b66\u6307\u6807\u6216\u57fa\u56e0\u578b\u7814\u7a76<\/p>\n<p>\u4e09\uff0c\u7cfb\u7edf\u4e4b\u95f4\u7684\u4ea4\u4e92\u4f5c\u7528<\/p>\n<p>\u56db\uff0c\u6cbb\u7597\u524d\u540e\u4e34\u5e8a\u7597\u6548+\u751f\u7269\u5b66\u6307\u6807<\/p>\n<p>\u7b49\u591a\u4e2a\u65b9\u9762\uff0c\u7ee7\u7eed\u8be6\u7ec6\u4ecb\u7ecd\u5982\u4f55\u5199\u4e00\u4e2a\u597d\u7684\u9898\u76ee\uff0c\u4ee5\u53ca\u66f4\u591a\u7684\u79d1\u7814\u601d\u8def\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<hr \/>\n<p>\u6ce8\uff1a\u672c\u6587\u662f\u7531\u5f20\u5411\u9633\u6559\u6388\u64b0\u5199\u7684\u300a\u6295\u7a3fSCI\u8bba\u6587\uff0c\u5982\u4f55\u5199\u4e00\u4e2a\u5438\u5f15\u4eba\u7684\u9898\u76ee+\u79d1\u7814\u601d\u8def\u300b\uff0c\u4ecb\u7ecd\u4e86\u5728\u5199\u8bba\u6587\u7684\u9898\u76ee\u65f6\uff0c\u5982\u4f55\u65e2\u4f53\u73b0\u6587\u7ae0\u7684\u5185\u5bb9\uff0c\u53c8\u4f53\u73b0\u7814\u7a76\u4e2d\u7684\u53d1\u73b0\uff0c\u8d77\u5230\u753b\u9f99\u70b9\u775b\u7684\u6548\u679c\u3002<\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u6211\u4eec\u6295\u7a3f\u65f6\uff0c\u4e3b\u7f16\u4ee5\u53ca\u5ba1\u7a3f\u8005\u9996\u5148\u770b\u5230\u7684\u5c31\u662f\u9898\u76ee\uff0c\u56e0\u6b64\u4e00\u4e2a\u5438\u5f15\u4eba\u7684\u9898\u76ee\u81f3\u5173\u91cd\u8981\uff0c\u751a\u81f3\u8d77\u7740\u753b\u9f99\u70b9\u775b\u7684\u6548\u679c\u3002\u4ee5\u524d\u6211\u6709\u4e2a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[10,14,38,56,74],"class_list":["post-64","post","type-post","status-publish","format-standard","hentry","category-5","tag-ithenticate","tag-sci","tag-38","tag-56","tag-74"],"_links":{"self":[{"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=\/wp\/v2\/posts\/64","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=64"}],"version-history":[{"count":0,"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=\/wp\/v2\/posts\/64\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=64"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=64"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=64"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}