{"id":613,"date":"2017-06-06T10:36:21","date_gmt":"2017-06-06T02:36:21","guid":{"rendered":"http:\/\/www.ithenticate.com.cn\/news\/?p=613"},"modified":"2017-06-06T10:36:21","modified_gmt":"2017-06-06T02:36:21","slug":"%e7%94%9f%e7%89%a9%e5%8c%bb%e5%ad%a6%e8%ae%ba%e6%96%87%e8%b6%8a%e5%86%99%e8%b6%8a%e5%a4%a7%ef%bc%8c%e5%b9%b2%e8%b4%a7%e8%b6%8a%e6%9d%a5%e8%b6%8a%e5%b0%91","status":"publish","type":"post","link":"https:\/\/www.ithenticate.com.cn\/news\/?p=613","title":{"rendered":"\u751f\u7269\u533b\u5b66\u8bba\u6587\u8d8a\u5199\u8d8a\u5927\uff0c\u5e72\u8d27\u8d8a\u6765\u8d8a\u5c11"},"content":{"rendered":"

\u4e0a\u4e16\u7eaa90\u5e74\u4ee3\uff0cWilliam G. Kaelin Jr.\u00a0\u548cGregg L. Semenza\u9769\u547d\u6027\u5730\u53d1\u73b0\u8ba9\u4eba\u4eec\u7406\u89e3\u4e86\u7ec6\u80de\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u611f\u53d7\u6c27\u6c14\u7684\u57fa\u672c\u539f\u7406\u3002\u4ed6\u4eec\u4e3b\u8981\u662f\u901a\u8fc7\u5bf9\u7ec6\u80de\u5185\u86cb\u767d\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u6c34\u5e73\u8c03\u8282\u673a\u5236\u7684\u6df1\u5165\u7814\u7a76\uff0c\u6700\u7ec8\u53d1\u73b0\u4e86\u7ec6\u80de\u611f\u53d7\u6c27\u6c14\u7684\u5206\u5b50\u57fa\u7840\u3002\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u662f\u4f4e\u6c27\u76f8\u5173\u57fa\u56e0\u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u80fd\u4fc3\u8fdb\u5404\u79cd\u5e94\u5bf9\u4f4e\u6c27\u7684\u57fa\u56e0\u8868\u8fbe\uff0c\u5728\u80bf\u7624\u53d1\u751f\u3001\u8840\u7ba1\u589e\u6b96\u3001\u65e0\u6c27\u4ee3\u8c22\u7b49\u7ec6\u80de\u57fa\u672c\u4ee3\u8c22\u8c03\u8282\u4e2d\u7684\u6838\u5fc3\u4e8b\u4ef6\u3002\u6700\u65e9\u7814\u7a76\u5c31\u53d1\u73b0\uff0c\u4f4e\u6c27\u6761\u4ef6\u4e0b\uff0c\u8bb8\u591a\u7ec6\u80de\u5185\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u6c34\u5e73\u589e\u52a0\u3002\u968f\u540e\u7814\u7a76\u8bc1\u660e\uff0c\u4f4e\u6c27\u5bfc\u81f4\u8fd9\u79cd\u86cb\u767d\u589e\u52a0\u7684\u539f\u56e0\u5e76\u4e0d\u662f\u901a\u8fc7\u4fc3\u8fdb\u57fa\u56e0\u8868\u8fbe\uff0c\u800c\u662f\u51cf\u5c11\u86cb\u767d\u5206\u89e3\u7684\u901f\u5ea6\u3002\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u5728\u7ec6\u80de\u5185\u88ab\u6cdb\u7d20\u5316\u540e\uff0c\u7ecf\u8fc7\u86cb\u767d\u9176\u6c34\u89e3\u3002\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u6cdb\u7d20\u5316\u7684\u6761\u4ef6\u662f\u9700\u8981\u812f\u6c28\u9178\u7f9f\u5316\uff0c\u812f\u6c28\u9178\u7f9f\u5316\u9700\u8981\u812f\u6c28\u9178\u7f9f\u5316\u9176\uff0c\u7f9f\u5316\u672c\u8d28\u4e0a\u662f\u6c27\u5316\uff0c\u812f\u6c28\u9178\u7f9f\u5316\u9176\u9700\u8981\u6c27\u6c14\u4f5c\u4e3a\u5e95\u7269\uff0c\u7f3a\u4e4f\u6c27\u6c14\u812f\u6c28\u9178\u7f9f\u5316\u9176\u5c31\u65e0\u6cd5\u53d1\u6325\u4f5c\u7528\uff0c\u5bfc\u81f4\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u6cdb\u7d20\u5316\u6c34\u89e3\u7684\u5931\u6548\uff0c\u7ed3\u679c\u662f\u8fd9\u79cd\u86cb\u767d\u5728\u7ec6\u80de\u5185\u79ef\u805a\u3002\u8fd9\u4e9b\u7814\u7a76\u8bc1\u660e\uff0c\u812f\u6c28\u9178\u7f9f\u5316\u9176\u5c31\u662f\u7ec6\u80de\u5185\u6c27\u6c14\u7684\u611f\u53d7\u5668\u3002\u4ed6\u4eec\u7684\u7814\u7a76\u8ba9\u6211\u4eec\u7406\u89e3\u7ec6\u80de\u662f\u5982\u4f55\u611f\u53d7\u6c27\u6c14\u8fd9\u79cd\u81f3\u5173\u91cd\u8981\u7684\u7269\u8d28\uff0c\u5177\u6709\u91cd\u8981\u7684\u4ef7\u503c\u3002\u6700\u8fd1Kaelin\u6559\u6388\u5728\u300a\u81ea\u7136\u300b\u6742\u5fd7\u64b0\u6587Publish houses ofbrick, not mansions of straw\uff0c\u547c\u5401\u62b5\u5236\u5b66\u672f\u6d6e\u8e81\uff0c\u591a\u7ed9\u79d1\u5b66\u5927\u53a6\u6dfb\u7816\u5854\uff0c\u5c11\u505a\u5f04\u4e00\u4e9b\u7a3b\u8349\u6837\u8bba\u6587\u3002<\/p>\n

Kaelin\u6559\u6388\u6587\u7ae0\u7b2c\u4e00\u53e5\u5c31\u8bf4\uff0c\u4ed6\u975e\u5e38\u62c5\u5fc3\u751f\u7269\u533b\u5b66\u7814\u7a76\u592a\u9a6c\u864e\u3002\u8bb8\u591a\u7814\u7a76\u7ed3\u679c\u53ea\u80fd\u5728\u975e\u5e38\u72ed\u7a84\u6761\u4ef6\u4e0b\u4f5c\u51fa\u6765\uff0c\u751a\u81f3\u65e0\u6cd5\u88ab\u91cd\u590d\u3002\u5bfc\u81f4\u8fd9\u79cd\u95ee\u9898\u7684\u539f\u56e0\u5f88\u591a\uff0c\u4f46\u4ed6\u8ba4\u4e3a\u7f6a\u9b41\u7978\u9996\u5f88\u96be\u786e\u5b9a\u3002\u751f\u7269\u533b\u5b66\u9886\u57df\u6700\u8fd1\u51e0\u5341\u5e74\u5448\u73b0\u51fa\u5feb\u901f\u53d1\u5c55\u7684\u8d8b\u52bf\uff0c\u5927\u91cf\u7814\u7a76\u6570\u636e\u548c\u58f0\u79f0\u4e0d\u65ad\u6d8c\u73b0\u51fa\u6765\uff0c\u7814\u7a76\u4eba\u5458\u88ab\u56f0\u5728\u8fd9\u79cd\u6570\u636e\u548c\u58f0\u79f0\u7684\u6f29\u6da1\u4e2d\uff0c\u597d\u50cf\u6162\u6162\u53d8\u70ed\u7684\u6c34\u716e\u9752\u86d9\u90a3\u6837\uff0c\u6162\u6162\u5730\u88ab\u8fd9\u79cd\u79d1\u7814\u6587\u5316\u5f71\u54cd\u548c\u4e60\u60ef\u3002\u5b66\u672f\u8bba\u6587\u7684\u76ee\u6807\u4e0d\u662f\u4e3a\u786e\u8ba4\u7279\u5b9a\u7ed3\u8bba\uff0c\u800c\u662f\u4e3a\u4e86\u5236\u9020\u66f4\u5e7f\u6cdb\u66f4\u591a\u58f0\u79f0\u3002\u8fd9\u79cd\u8bba\u6587\u7684\u5371\u9669\u53ea\u662f\u589e\u52a0\u4e86\u8bb8\u591a\u7a3b\u8349\u5efa\u7b51\uff0c\u800c\u4e0d\u662f\u7816\u74e6\u623f\u3002\u751f\u7269\u533b\u5b66\u7814\u7a76\u8bba\u6587\u8d8a\u5199\u8d8a\u957f\uff0c\u7814\u7a76\u65b9\u6cd5\u8d8a\u6765\u8d8a\u82b1\u54e8\uff0c\u7814\u7a76\u7ed3\u8bba\u8d8a\u6765\u8d8a\u591a\uff0c\u4f46\u660e\u786e\u575a\u5b9e\u7684\u7ed3\u8bba\u76f8\u5bf9\u51cf\u5c11\u3002<\/p>\n

2016\u5e74\u62c9\u65af\u514b\u57fa\u7840\u533b\u5b66\u5956\u88abWilliam Kaelin\u3001Peter Ratcliffe\u548cGregg Semenza\u4e09\u4f4d\u5206\u4eab\uff0c\u4ee5\u5956\u52b1\u4ed6\u4eec\u5728\u53d1\u73b0\u52a8\u7269\u7ec6\u80de\u611f\u53d7\u548c\u9002\u5e94\u6c27\u6c14\u6c34\u5e73\u6539\u53d8\u7684\u5206\u5b50\u673a\u5236\uff0c\u6c27\u6c14\u611f\u53d7\u4fe1\u53f7\u7cfb\u7edf\u5728\u8bb8\u591a\u751f\u7406\u548c\u75c5\u7406\u8fc7\u7a0b\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002Kaelin\u6559\u6388\u56de\u987e\u4e86\u81ea\u5df1\u83b7\u5956\u7684\u7814\u7a76\u8bba\u6587\u7684\u60c5\u51b5\uff0c\u8fd9\u4e9b\u8bba\u6587\u90fd\u662f10\u5e74\u524d\u53d1\u8868\uff0c\u5927\u591a\u6570\u90fd\u53ef\u4ee5\u88ab\u770b\u4f5c\u53e4\u602aquaint\u3001\u521d\u6b65\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u6309\u7167\u73b0\u5728\u7684\u8bba\u6587\u53d1\u8868\u6807\u51c6\u51e0\u4e4e\u65e0\u6cd5\u53d1\u8868\u3002\u4ed6\u4eec\u53d1\u73b0\u4e00\u79cd\u80bf\u7624\u6291\u5236\u86cb\u767d\uff08VHL\uff09\u662f\u6c27\u6c14\u4fe1\u53f7\u5fc5\u987b\u7684\uff0c\u8fd9\u6837\u7684\u7814\u7a76\u7ed3\u679c\u653e\u5728\u73b0\u5728\u53ef\u80fd\u4f1a\u88ab\u6279\u8bc4\u7f3a\u4e4f\u6e05\u695a\u673a\u5236\u548c\u52a8\u7269\u5b9e\u9a8c(O. Iliopoulos et al. Proc. Natl Acad. Sci. USA 93,10595\u201310599; 1996)\u3002\u53e6\u5916\u4e00\u4e2a\u7814\u7a76\u662f\u53d1\u73b0\u8fd9\u4e2aVHL\u86cb\u767d\u7684\u4e3b\u8981\u76ee\u6807\u53d7\u5230\u6c27\u6c14\u4f9d\u8d56\u4fee\u9970\uff0c\u8fd9\u4e2a\u8bba\u6587\u5219\u906d\u53d7\u51e0\u4e4e\u88ab\u300a\u79d1\u5b66\u300b\u62d2\u7a3f\u7684\u7ed3\u5c40\uff0c\u56e0\u4e3a\u7814\u7a76\u8fd8\u6ca1\u6709\u627e\u5230\u5177\u4f53\u90a3\u79cd\u9176\u8d1f\u8d23\u8fd9\u79cd\u4fee\u9970\u8fc7\u7a0b(M. Ivan et al. Science 292, 464\u2013468; 2001)\u3002\u5e78\u8fd0\u7684\u662f\uff0c\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u7684\u4e00\u4e2a\u5b9e\u9a8c\u7f16\u8f91\u53d1\u8bdd\uff0c\u8ba4\u4e3a\u53d1\u8868\u8be5\u8bba\u6587\u5bf9\u63a8\u52a8\u5176\u5b83\u7814\u7a76\u5c0f\u7ec4\u5bfb\u627e\u8fd9\u79cd\u9176\u6709\u4f5c\u7528\u3002\u4f46\u662f\u8fd9\u6837\u7684\u60c5\u51b5\u73b0\u5728\u8d8a\u6765\u8d8a\u4e0d\u666e\u904d\u3002<\/p>\n

\u662f\u4ec0\u4e48\u5bfc\u81f4\u4eca\u5929\u7684\u7814\u7a76\u58f0\u79f0\u81a8\u80c0\uff08claims inflation\uff09\uff1f\u4e00\u4e2a\u56e0\u7d20\u662f\u8d44\u52a9\u673a\u6784\u8fc7\u4e8e\u5f3a\u8c03\u5b66\u672f\u5f71\u54cd\u529b\u548c\u8f6c\u5316\uff08\u6211\u4eec\u53ef\u80fd\u8ba4\u4e3a\uff0c\u5b66\u672f\u5f71\u54cd\u529b\u548c\u8f6c\u5316\u5e94\u7528\u662f\u975e\u5e38\u653f\u6cbb\u6b63\u786e\u7684\uff09\u3002\u53e6\u5916\u4e00\u4e2a\u56e0\u7d20\u662f\uff0c\u6280\u672f\u8fdb\u6b65\u8ba9\u6570\u636e\u6536\u96c6\u53d8\u7684\u8d8a\u6765\u8d8a\u5bb9\u6613\uff0c\u8fd9\u4e9b\u6570\u636e\u53ef\u4ee5\u7528\u7f51\u7edc\u9644\u4ef6\u65b9\u5f0f\u3002\u4e24\u79cd\u56e0\u7d20\u9f13\u52b1\u8bc4\u8bba\u5458\u548c\u7f16\u8f91\u5411\u6295\u7a3f\u4eba\u63d0\u51fa\u989d\u5916\u5b9e\u9a8c\u8981\u6c42\uff0c\u4ee5\u589e\u52a0\u7ed3\u8bba\u7684\u53ef\u9760\u6027\u548c\u8bba\u6587\u7684\u5f71\u54cd\u529b\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u7a3f\u4ef6\u652f\u6301\u7ed3\u8bba\u7684\u5b9e\u9a8c\u6570\u636e\u8d8a\u591a\u8d8a\u5bb9\u6613\u88ab\u63a5\u53d7\u3002\u8fd9\u5bb9\u6613\u5bfc\u81f4\u54ea\u4e9b\u66f4\u7b26\u5408\u9884\u671f\u7684\u7814\u7a76\u7ed3\u679c\u66f4\u5bb9\u6613\u88ab\u63a5\u53d7\u3002\u66f4\u8ba9\u4eba\u62c5\u5fc3\u7684\u662f\uff0c\u5f53\u7ecf\u8d39\u89c4\u6a21\u76f8\u5bf9\u7d27\u5f20\u65f6\uff0c\u57fa\u91d1\u8bc4\u5ba1\u5458\u4f1a\u5bf9\u6709\u98ce\u9669\u9879\u76ee\u5927\u5f00\u6740\u6212\u3002<\/p>\n

\u6700\u8fd1\u4e00\u6bb5\u65f6\u95f4\uff0c\u8bba\u6587\u56fe1\u653e\u4e00\u4e2a\u6709\u8da3\u7684\u89c2\u5bdf\u63cf\u8ff0\uff0c\u5bfc\u81f4\u4e00\u7cfb\u5217\u9c81\u68d2\u6027\u5b9e\u9a8c\u7684\u7814\u7a76\u6a21\u5f0f\u3002Kaelin\u6559\u6388\u535a\u58eb\u540e\u671f\u95f4\uff0c\u4e00\u7bc7\u8bba\u6587\u53ea\u9700\u8981\u6d4b\u5b9a\u4e24\u79cd\u86cb\u767d\u8d28\u80fd\u7ed3\u5408\u5728\u4e00\u8d77\uff0c\u7136\u540e\u7528\u6d3b\u7ec6\u80de\u5b9e\u9a8c\u8bc1\u660e\u8fd9\u79cd\u7ed3\u5408\u4e5f\u540c\u6837\u51fa\u73b0\u5728\u7ec6\u80de\u5185\u3002\u4eca\u5929\u7684\u8bba\u6587\u5982\u679c\u8981\u652f\u6301\u8fd9\u79cd\u65ad\u8a00\uff0c\u5fc5\u987b\u6709\u4e00\u4e24\u4e2a\u63cf\u8ff0\u6027\u5b9e\u9a8c\u653e\u5728\u56fe1\uff08\u6216\u8bb8\u8fd8\u9700\u8981\u4e00\u4e9b\u8865\u5145\u6750\u6599\u653e\u5728\u9644\u4ef6\u4e2d\uff09\uff0c\u8bba\u6587\u7684\u5176\u4f59\u90e8\u5206\u5c06\u63cf\u8ff0\u5de5\u4f5c\u8de8\u8d8a\u4e8e\u4e0d\u540c\u5b66\u79d1\uff0c\u4ece\u5206\u5b50\u751f\u7269\u5b66\u5230\u529f\u80fd\u884c\u4e3a\u5b66\uff0c\u751a\u81f3\u9700\u8981\u548c\u4e34\u5e8a\u75be\u75c5\u8054\u7cfb\u8d77\u6765\uff0c\u8fd9\u6837\u624d\u80fd\u663e\u793a\u51fa\u7814\u7a76\u7684\u5e7f\u5ea6\u548c\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\n

\u4e0d\u5e78\u7684\u662f\uff0c\u8fd9\u79cd\u7814\u7a76\u5e7f\u5ea6\u7684\u8ffd\u6c42\u7ecf\u5e38\u4f1a\u4ee5\u727a\u7272\u6df1\u5ea6\u4e3a\u4ee3\u4ef7\u3002\u4efb\u4f55\u6280\u672f\u548c\u65b9\u6cd5\u90fd\u5b58\u5728\u5c40\u9650\u6027\uff0c\u4e3a\u4e86\u83b7\u5f97\u4e00\u4e2a\u660e\u786e\u7684\u7ed3\u8bba\uff0c\u751f\u7269\u533b\u5b66\u7814\u7a76\u9700\u8981\u91c7\u7528\u4e0d\u540c\u89d2\u5ea6\u7684\u6280\u672f\u53cd\u590d\u8fdb\u884c\u7814\u7a76\u3002\u4f8b\u5982\u4e3a\u4e86\u7814\u7a76\u67d0\u4e2a\u5206\u5b50\u5728\u67d0\u79cd\u75be\u75c5\u4e2d\u7684\u529f\u80fd\uff0c\u6211\u4eec\u9700\u8981\u86cb\u767d\u5b9a\u91cf\u7814\u7a76\uff0c\u4e5f\u9700\u8981\u57fa\u56e0\u8868\u8fbe\u7684\u6570\u636e\u548c\u5f62\u6001\u5b66\u5206\u5e03\u5b9a\u4f4d\u4fe1\u606f\u3002\u5f53\u524d\u7814\u7a76\u8bba\u6587\u5f80\u5f80\u6709\u591a\u4e2a\u58f0\u79f0\uff0c\u6bcf\u4e2a\u58f0\u79f0\u7684\u8bc1\u636e\u90fd\u6bd4\u8f83\u5355\u8584\uff0c\u8fd9\u6837\u4f1a\u8ba9\u7814\u7a76\u8bba\u6587\u53d8\u5f97\u865a\u80d6\u4f46\u4e0d\u8e0f\u5b9e\u3002<\/p>\n

\u8de8\u5ea6\u5927\u58f0\u79f0\u591a\u4e5f\u7ed9\u540c\u884c\u8bc4\u8bae\u7cfb\u7edf\u5e26\u6765\u56f0\u96be\u3002\u867d\u7136Kaelin\u6559\u6388\u662f\u4e2a\u8001\u6c5f\u6e56\uff0c\u800c\u4e14\u4e5f\u5728\u4e0d\u540c\u9886\u57df\u6709\u7814\u7a76\u7ecf\u5386\uff0c\u4f46\u662f\u4e5f\u7ecf\u5e38\u9047\u5230\u4e0d\u719f\u6089\u7684\u8bba\u6587\u7a3f\u4ef6\u3002\u5982\u679c\u8fd9\u79cd\u8d8b\u52bf\u7ee7\u7eed\u53d1\u5c55\uff0c\u6742\u5fd7\u5c06\u975e\u5e38\u96be\u627e\u5230\u5408\u683c\u7684\u8bc4\u8bba\u5458\u3002\u7f16\u8f91\u91c7\u7528\u5177\u6709\u4e92\u8865\u5b66\u672f\u80cc\u666f\u7684\u5b66\u8005\u8bc4\u5ba1\u4e00\u7bc7\u8bba\u6587\u53ef\u4ee5\u6ee1\u8db3\u9700\u8981\uff0c\u4f46\u662f\u8fd9\u4f1a\u7ed9\u8bc4\u5ba1\u5e26\u6765\u6bd4\u8f83\u5927\u7684\u96be\u5ea6\u3002\u5bf9\u8bba\u6587\u9644\u4ef6\u7684\u5ba1\u67e5\uff0c\u8bc4\u5ba1\u5458\u4e5f\u4e00\u822c\u4e0d\u591f\u91cd\u89c6\u3002<\/p>\n

\u53e6\u5916\u4e00\u4e2a\u4e0d\u826f\u540e\u679c\u662f\u5bfc\u81f4\u5b66\u672f\u4ea4\u6d41\u5ef6\u8fdf\u548c\u804c\u4e1a\u8bad\u7ec3\u96be\u5ea6\u589e\u5927\u3002\u6ca1\u6709\u56de\u7b54\u7684\u95ee\u9898\u548c\u6ca1\u6709\u89e3\u91ca\u7684\u7ed3\u679c\u7ecf\u5e38\u88ab\u8ba4\u4e3a\u5dee\u7684\u7814\u7a76\uff0c\u5f88\u96be\u88ab\u6742\u5fd7\u63a5\u53d7\u53d1\u8868\u3002\u8fd9\u4f1a\u5bfc\u81f4\u4e00\u4e9b\u574f\u4e60\u60ef\u7684\u53d1\u751f\uff0c\u4f8b\u5982\u4e3a\u53d1\u8868\u8bba\u6587\u6311\u6570\u636e\u7684\u884c\u4e3a\u3002\u6211\u4eec\u5fc5\u987b\u9f13\u52b1\u54ea\u4e9b\u8bda\u5b9e\u8868\u8fbe\u7814\u7a76\u5c40\u9650\u548c\u77db\u76fe\u7ed3\u679c\u7684\u7814\u7a76\u8bba\u6587\u3002<\/p>\n

\u77e5\u8bc6\u7f3a\u4e4f\u624d\u662f\u4e34\u5e8a\u8f6c\u5316\u771f\u6b63\u7684\u74f6\u9888\u3002\u6211\u4eec\u5e94\u8be5\u505c\u6b62\u544a\u8bc9\u57fa\u7840\u79d1\u5b66\u5bb6\uff0c\u5c24\u5176\u662f\u79d1\u7814\u65b0\u624b\uff0c\u7814\u7a76\u5de5\u4f5c\u4ef7\u503c\u5728\u4e8e\u53ef\u8f6c\u5316\u5e94\u7528\u6027\u3002\u6211\u4eec\u5fc5\u987b\u56de\u5230\u66f4\u4ed4\u7ec6\u68c0\u67e5\u7814\u7a76\u8bba\u6587\u539f\u521b\u6027\u3001\u5b9e\u9a8c\u8bbe\u8ba1\u548c\u6570\u636e\u8d28\u91cf\u7684\u7ecf\u5178\u8f68\u9053\u4e0a\u6765\u3002\u91c7\u53d6\u66f4\u8c28\u614e\u7684\u6001\u5ea6\u9884\u6d4b\u5f71\u54cd\u529b\uff0c\u771f\u6b63\u7684\u79d1\u5b66\u548c\u5e94\u7528\u4ef7\u503c\u53ea\u80fd\u7b49\u5f85\u672a\u6765\u7684\u8bc4\u4ef7\u3002\u4e00\u4e9b\u6709\u9769\u547d\u6027\u610f\u4e49\u7684\u5b66\u672f\u53d1\u73b0\u5982\u9650\u5236\u6027\u5185\u5207\u9176\u3001\u9175\u6bcd\u7ec6\u80de\u5faa\u73af\u7a81\u53d8\u4f53\u548cCRISPR-Cas9\u66fe\u7ecf\u88ab\u8ba4\u4e3a\u53ea\u662f\u610f\u5916\u7ed3\u679c\u3002\u6211\u4eec\u5e94\u8be5\u66f4\u52a0\u91cd\u89c6\u7814\u7a76\u5de5\u4f5c\u672c\u8eab\u7684\u8d28\u91cf\uff0c\u4ee5\u53ca\u662f\u5426\u80fd\u5e26\u6765\u66f4\u591a\u53d1\u73b0\uff0c\u4e0d\u8981\u8fc7\u4e8e\u5728\u610f\u5177\u4f53\u8bba\u6587\u53d1\u8868\u5728\u4ec0\u4e48\u6742\u5fd7\u4e0a\u3002<\/p>\n

\u8bc4\u5ba1\u8bba\u6587\u6700\u91cd\u8981\u7684\u662f\u770b\u7814\u7a76\u7ed3\u8bba\u662f\u5426\u6b63\u786e\uff0c\u800c\u4e0d\u8981\u5bf9\u91cd\u8981\u6027\u8fc7\u4e8e\u770b\u91cd\u3002\u771f\u6b63\u7684\u79d1\u5b66\u5927\u53a6\u662f\u7528\u5177\u4f53\u53ef\u9760\u7684\u4e00\u7816\u4e00\u74e6\u5efa\u7b51\u8d77\u6765\u7684\uff0c\u800c\u4e0d\u662f\u7528\u534e\u4e3d\u4f46\u4e0d\u575a\u56fa\u7684\u7a3b\u8349\u3002<\/strong><\/p>\n

\n
\n
\u7248\u6743\u58f0\u660e<\/strong><\/p>\n<\/section>\n<\/section>\n

\u672c\u6587\u8f6c\u8f7d\u81ea\u5b59\u5b66\u519b\u79d1\u5b66\u7f51\u535a\u5ba2\u3002\u6587\u7ae0\u8f6c\u8f7d\u53ea\u4e3a\u5b66\u672f\u65b0\u95fb\u4fe1\u606f\u7684\u4f20\u64ad\u3002<\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u4e16\u7eaa90\u5e74\u4ee3\uff0cWilliam G. Kaelin Jr.\u00a0\u548cGregg L. Semenza\u9769\u547d\u6027\u5730\u53d1\u73b0\u8ba9\u4eba […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-613","post","type-post","status-publish","format-standard","hentry","category-2"],"_links":{"self":[{"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=\/wp\/v2\/posts\/613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=613"}],"version-history":[{"count":0,"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=\/wp\/v2\/posts\/613\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ithenticate.com.cn\/news\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}