{"id":1855,"date":"2018-08-06T17:36:59","date_gmt":"2018-08-06T09:36:59","guid":{"rendered":"http:\/\/www.ithenticate.com.cn\/news\/?p=1855"},"modified":"2018-08-06T17:36:59","modified_gmt":"2018-08-06T09:36:59","slug":"%e5%8c%bb%e5%ad%a6%e7%a0%94%e7%a9%b6%e7%94%9f%e8%8b%b1%e6%96%87sci%e8%ae%ba%e6%96%87%e5%86%99%e4%bd%9c%e5%b8%b8%e8%a7%81%e7%9a%84%e8%af%ad%e8%a8%80%e9%97%ae%e9%a2%98%e5%88%86%e6%9e%90","status":"publish","type":"post","link":"https:\/\/www.ithenticate.com.cn\/news\/?p=1855","title":{"rendered":"\u533b\u5b66\u7814\u7a76\u751f\u82f1\u6587SCI\u8bba\u6587\u5199\u4f5c\u5e38\u89c1\u7684\u8bed\u8a00\u95ee\u9898\u5206\u6790"},"content":{"rendered":"

\u64b0\u5199\u4e0e\u53d1\u8868\u82f1\u6587SCI\u8bba\u6587\u662f\u533b\u5b66\u7814\u7a76\u751f\u7684\u6e34\u671b, \u800c\u9762\u4e34\u7684\u8bed\u8a00\u56f0\u96be\u5e38\u4f7f\u5f88\u591a\u4eba\u671b\u800c\u751f\u754f\u3002\u73b0\u5c06\u533b\u5b66\u751f\u64b0\u5199SCI\u8bba\u6587\u5e38\u89c1\u8bed\u8a00\u95ee\u9898\u505a\u4ee5\u5206\u6790\u5e76\u63d0\u4f9b\u76f8\u5e94\u7684\u4fee\u6539\u5efa\u8bae,\u4ee5\u671f\u5728\u8bed\u8a00\u8868\u8fbe\u5c42\u9762\u63d0\u9ad8\u533b\u5b66\u751f\u82f1\u6587SCI\u8bba\u6587\u7684\u5199\u4f5c\u6c34\u5e73, \u63d0\u5347\u5176\u79d1\u7814\u80fd\u529b\u3002<\/p>\n

\"\"<\/a><\/p>\n

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\u00a0 \u00a0 \u00a0 \u00a0\u5b58\u5728\u7684\u8bed\u8a00\u95ee\u9898<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/article>\n
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\u00a0 \u00a0 \u00a0 \u00a0\u6587\u4f53\u4e0d\u7b26\u5408\u5b66\u672f\u8bba\u6587\u7684\u89c4\u8303<\/p>\n<\/section>\n<\/section>\n
\u00a0 \u00a0 \u00a0 \u00a0\u8bed\u8a00\u8868\u8fbe\u6709\u4e66\u9762\u8bed\u4e0e\u53e3\u5934\u8bed\u4e4b\u5206, \u800c\u4e66\u9762\u8bed\u53c8\u53ef\u636e\u5176\u4f7f\u7528\u7684\u8303\u56f4\u4e0e\u76ee\u7684\u5206\u4e3a\u201c\u79d1\u5b66\u8bed\u4f53\u3001\u6587\u5b66\u8bed\u4f53\u3001\u653f\u8bba\u8bed\u4f53\u201d\u7b49\u82e5\u5e72\u7c7b\u3002\u800c\u5b66\u672f\u8bba\u6587\u5c5e\u4e8e\u79d1\u5b66\u8bed\u4f53, \u662f\u201c \u670d\u52a1\u4e8e\u67d0\u4e2a\u9650\u5b9a\u9886\u57df\u7684\u7ecf\u9a8c\u548c\u884c\u4e3a\u201d\u7684\u8bed\u8a00, \u6709\u5176\u81ea\u8eab\u7684\u8bed\u6cd5\u548c\u8bcd\u6c47\u7279\u5f81, \u5373\u53e5\u5b50\u957f;\u5e38\u7528\u590d\u6742\u7684\u540d\u8bcd\u6216\u540d\u8bcd\u6027\u77ed\u8bed\u3001\u590d\u5408\u53e5\u5f0f\u3001\u975e\u9650\u5b9a\u6027\u4ece\u53e5\u3001\u975e\u8c13\u8bed\u52a8\u8bcd\u53ca\u88ab\u52a8\u8bed\u6001\u3002\u800c\u533b\u5b66\u751f\u5728\u64b0\u5199\u8bba\u6587\u65f6, \u5f80\u5f80\u53ea\u8003\u8651\u627e\u5230\u80fd\u591f\u8868\u8fbe\u81ea\u5df1\u89c2\u70b9\u7684\u65b9\u5f0f, \u6ca1\u6709\u8003\u8651\u5230\u8be5\u8868\u8fbe\u65b9\u5f0f\u662f\u4e66\u9762\u8bed\u8fd8\u662f\u53e3\u8bed,\u56e0\u800c\u5728\u884c\u6587\u4e2d,\u4e66\u9762\u8bed\u4e0e\u53e3\u8bed\u63ba\u6742\u5728\u4e00\u8d77,\u5f80\u5f80\u4f1a\u51fa\u73b0\u4ee4\u4eba\u8d39\u89e3\u3001\u8bef\u89e3\u3001\u8bed\u4e49\u542b\u7cca\u4e0d\u6e05\u7684\u73b0\u8c61\u3002<\/p>\n

\u4f8b1:OS is the most important indicator of clinical efficacy end-point for any treatment regimen for long before.<\/p>\n

\u672c\u53e5\u4e2d\u7684\u00a0for long before \u662f\u53e3\u8bed\u5316\u8868\u8fbe\u65b9\u5f0f,\u4e0d\u7b26\u5408\u4e66\u9762\u8bed\u4f53\u8981\u6c42,\u5176\u4e2d\u7684\u7cfb\u8868\u7ed3\u6784, \u4e5f\u6709\u5f31\u5316\u5b66\u672f\u6027\u4e4b\u5acc, \u53ef\u6539\u4e3a:<\/p>\n

OS has\u00a0long\u00a0been\u00a0accepted\u00a0as\u00a0the\u00a0most\u00a0important \u00a0indicator of\u00a0clinical efficacy endpoint for any treatment regimen .<\/p>\n<\/section>\n<\/section>\n<\/article>\n<\/section>\n<\/section>\n

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\u00a0 \u00a0 \u00a0 \u00a0\u4eba\u79f0\u4f7f\u7528\u4e0d\u7b26\u5408\u5b66\u672f\u8bba\u6587\u7684\u5ba2\u89c2\u6027\u8981\u6c42<\/p>\n<\/section>\n<\/section>\n
\u00a0 \u00a0 \u00a0 \u00a0\u5b66\u672f\u8bba\u6587\u8981\u6c42\u4ee5\u7b2c\u4e09\u4eba\u79f0\u6765\u64b0\u5199\u4ee5\u8868\u660e\u7814\u7a76\u7684\u5ba2\u89c2\u6027\u3002\u7531\u4e8e\u53d7\u5230\u6bcd\u8bed\u7684\u5e72\u6270, \u6211\u56fd\u7684\u8bba\u6587\u5e38\u5e38\u4f1a\u51fa\u73b0our , us we, my\u7b49\u5b57\u6837, \u4e25\u91cd\u5f71\u54cd\u884c\u6587\u7684\u5ba2\u89c2\u6027\u3002\u539f\u56e0\u5728\u4e8e\u4f5c\u8005\u4e0d\u662f\u4e0d\u77e5\u9053\u8981\u907f\u514d\u4f7f\u7528\u7b2c\u4e00\u4eba\u79f0, \u66f4\u591a\u7684\u662f\u4e0d\u77e5\u9053\u5982\u679c\u907f\u514d\u4f7f\u7528\u7b2c\u4e00\u4eba\u79f0, \u5982:<\/p>\n

\u4f8b2:In\u00a0this\u00a0study , we\u00a0included\u00a0197\u00a0patients\u00a0with \u00a0advanced non-small\u00a0cell\u00a0lung cancer as our\u00a0sample.<\/p>\n

\u4f8b3:Our\u00a0aim is to testify the relationship between PFS \u00a0and OS of patients with advanced NSCLC .<\/p>\n

\u4f8b4 :This study\u00a0gives\u00a0us\u00a0the hint\u00a0that\u00a0PFS\u00a0is more\u00a0reliable \u00a0in\u00a0predicting\u00a0the effectiveness of\u00a0first-line chemotherapy .<\/p>\n

\u4ee5\u4e0a\u7684\u4f8b\u5b50\u4e2d\u53ef\u4ee5\u5206\u522b\u4fee\u6539\u4e3a:<\/p>\n

Altogether 197 patients with advanced non-small cell lung can- cer were included in this study .<\/p>\n

The aim is to testify the relationship between PFS and OS of pa- tients with advanced NSCLC .<\/p>\n

This study indicates that PFS is more reliable in predicting the effectiveness of\u00a0first-line chemotherapy .<\/p>\n

\u8fd9\u6837\u65e2\u80fd\u8868\u8fbe\u4f5c\u8005\u6240\u8981\u8868\u8ff0\u7684\u5185\u5bb9, \u53c8\u663e\u9732\u51fa\u884c\u6587\u7684\u5ba2\u89c2\u516c\u6b63\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/article>\n<\/section>\n

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\u00a0 \u00a0 \u00a0 \u00a0\u5b58\u5728\u7b80\u5355\u7684\u6c49\u82f1\u4e92\u8bd1\u73b0\u8c61<\/p>\n<\/section>\n<\/section>\n
\u00a0 \u00a0 \u00a0 \u00a0\u6211\u56fd\u533b\u5b66\u751f\u503e\u5411\u4e8e\u5148\u5f62\u6210\u4e2d\u6587\u7684\u5b66\u672f\u8bba\u6587, \u7136\u540e\u518d\u5c06\u5176\u7ffb\u8bd1\u6210\u82f1\u6587\u3002\u4ee5\u4e3a\u8fd9\u6837\u65e2\u53ef\u4ee5\u4fdd\u6301\u601d\u7ef4\u7684\u8fde\u7eed\u6027, \u53c8\u7b80\u5355\u6613\u884c\u3002\u6b8a\u4e0d\u77e5, \u82f1\u8bed\u548c\u6c49\u8bed\u7684\u8868\u8fbe\u65b9\u5f0f\u5e76\u4e0d\u662f\u4e00\u4e00\u5bf9\u5e94\u7684\u5173\u7cfb, \u9700\u8981\u76f8\u5e94\u7684\u8bed\u8a00\u6587\u5316\u80cc\u666f\u77e5\u8bc6\u53ca\u6587\u5b57\u529f\u5e95\u4f5c\u4e3a\u4f9d\u6258, \u624d\u80fd\u4f7f\u8bd1\u6587\u8131\u79bb\u7ffb\u8bd1\u7684\u75d5\u8ff9\u3002\u533b\u5b66\u751f\u672c\u8eab\u5c31\u4e0d\u5177\u5907\u8fd9\u6837\u82f1\u8bed\u8bed\u8a00\u57fa\u7840\u548c\u6587\u5316\u5e95\u8574, \u6b64\u6cd5\u6240\u5199\u7684\u8bba\u6587\u8bed\u6cd5\u3001\u8bed\u7528\u9519\u8bef\u8fde\u7bc7, \u4f8b\u5982,\u4e0d\u5c11\u5b66\u751f\u4f1a\u628a\u201c \u8fd9\u4e5f\u8bb8\u662f\u56e0\u4e3a\u6211\u4eec\u5ffd\u89c6\u4e86\u4e00\u4e9b\u56e0\u7d20, \u5982\u2026\u201d \u7ffb\u8bd1\u5982\u4e0b:<\/p>\n

\u4f8b5 :It is maybe because we have ignored some factors, such as\u2026 .<\/p>\n

\u5728\u82f1\u8bed\u4e2d, maybe\u662f\u4e2a\u526f\u8bcd, \u901a\u5e38\u7f6e\u4e8e\u52a8\u8bcd\u4e4b\u524d\u6216\u653e\u4e8e\u53e5\u9996, \u8868\u793a\u4e00\u79cd\u53ef\u80fd\u6027, \u800cbecause\u662f\u539f\u56e0\u72b6\u8bed\u4ece\u53e5\u7684\u5f15\u5bfc\u8bcd, \u7528\u76f4\u8bd1\u7684\u65b9\u6cd5\u628a\u8fd9\u4e24\u4e2a\u6839\u672c\u4e0d\u80fd\u642d\u754c\u7684\u8bcd\u4f3c\u4e4e\u201c \u901a\u987a\u201d\u5730\u653e\u5728\u4e86\u4e00\u8d77, \u5f62\u6210\u4e86\u53ea\u6709\u4e2d\u56fd\u4eba\u624d\u80fd\u770b\u61c2\u7684\u4e2d\u5f0f\u82f1\u8bed\u3002\u6b63\u786e\u7ffb\u8bd1\u5982\u4e0b:Maybe some factors , such as\u2026 , have been ignored.<\/p>\n

\u4e3a\u4e86\u907f\u514d\u76f4\u8bd1\u6240\u9020\u6210\u7684\u9ebb\u70e6,\u5728\u64b0\u5199\u8bba\u6587\u4e4b\u521d,\u64b0\u7a3f\u4eba\u5e94\u5148\u67e5\u9605\u76f8\u5173\u7684\u82f1\u8bed\u6587\u732e,\u4ee5\u5f62\u6210\u4e00\u5b9a\u7684\u82f1\u8bed\u601d\u7ef4\u4e60\u60ef,\u638c\u63e1\u82f1\u8bed\u7684\u8868\u8fbe\u65b9\u5f0f\u4e0e\u65b9\u6cd5, \u5e76\u7528\u8fd9\u6837\u7684\u65b9\u6cd5\u628a\u81ea\u5df1\u6240\u8981\u4f20\u8fbe\u7684\u5185\u5bb9\u8868\u8ff0\u51fa\u6765,\u66f4\u5bb9\u6613\u64b0\u5199\u51fa\u9ad8\u8d28\u91cf\u7684SCI\u5b66\u672f\u8bba\u6587\u3002<\/p>\n<\/section>\n<\/section>\n<\/article>\n<\/section>\n

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\u8fde\u8bcd\u4f7f\u7528\u7f3a\u5931\u6216\u4f7f\u7528\u4e0d\u5f53<\/p>\n<\/section>\n<\/section>\n
\u82f1\u8bed\u5b66\u672f\u8bba\u6587\u503e\u5411\u4e8e\u4f7f\u7528\u591a\u79cd\u4ece\u53e5\u4e0e\u77ed\u8bed\u628a\u591a\u4e2a\u7b80\u5355\u7684\u53e5\u5b50\u8fde\u63a5\u5230\u4e00\u8d77, \u5f62\u6210\u4e00\u4e2a\u6216\u591a\u4e2a\u590d\u5408\u53e5\u5f0f;\u800c\u5728\u4e24\u4e2a\u6216\u591a\u4e2a\u7b80\u5355\u53e5\u4e2d\u95f4, \u4e5f\u8981\u6709\u4e00\u5b9a\u7684\u8fde\u63a5\u8bcd\u8bed\u8854\u63a5, \u4ee5\u4fdd\u8bc1\u884c\u6587\u662f\u4e00\u4e2a\u8fde\u7eed\u7684\u6574\u4f53\u3002 \u5982\u679c\u7f3a\u5931\u4e86\u5c31\u4f1a\u964d\u4f4e\u8bba\u6587\u7684\u53ef\u8bfb\u6027\u3002\u5982:<\/p>\n

\u4f8b6:PFS is a biological indicator .It can measure tumor burden directly\u00a0.PFS\u00a0can\u00a0accurately\u00a0and swiftly\u00a0indicate the\u00a0survival\u00a0benefit\u00a0of their firs-t line therapy .It\u00a0enables \u00a0clinicians to\u00a0modify their treat- ment projects as soon as possible .It has been accepted as a surrogate for OS\u00a0in \u00a0advanced\u00a0cancer.<\/p>\n

\u8fd9\u6bb5\u884c\u6587\u7531\u4e94\u4e2a\u7b80\u5355\u7684\u53e5\u5b50\u6784\u6210, \u653e\u5728\u4e00\u8d77\u6709\u4e00\u79cd\u91cd\u590d\u800c\u53c8\u6ca1\u6709\u7a81\u51fa\u91cd\u70b9\u7684\u611f\u89c9, \u53ef\u4ee5\u628a\u7b2c\u4e8c\u4e2a\u5355\u53e5\u5f53\u4f5c\u540c\u4f4d\u8bed, \u628a\u7b2c\u4e09\u548c\u7b2c\u56db\u53e5\u5408\u5e76, \u505a\u6210\u975e\u9650\u5b9a\u6027\u5b9a\u8bed\u4ece\u53e5 , \u53ef\u6539\u4e3a:<\/p>\n

PFS , a biological indicator , which can accurately and swiftly in- dicate the survival benefit of first-line therapy , and thus enables\u00a0clin- icians to modify their treatment projects as early as possible , has long been accepted as a surrogate for OS in advanced cancer.<\/p>\n

\u4fee\u6539\u540e\u7684\u884c\u6587\u4e00\u6c14\u5475\u6210, \u800c\u4e14\u7a81\u51fa\u4e86 PFS \u53ef\u7528\u6765\u66ff\u4ee3OS\u8fd9\u4e00\u884c\u6587\u4e2d\u7684\u91cd\u70b9,\u53ef\u8bfb\u6027\u66f4\u5f3a\u3002<\/p>\n<\/section>\n<\/section>\n<\/article>\n<\/section>\n

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\u00a0 \u00a0 \u00a0 \u00a0\u82f1\u8bed\u533a\u522b\u4e0e\u6c49\u8bed\u7684\u4e00\u4e2a\u663e\u8457\u7684\u7279\u70b9\u5c31\u662f\u5176\u52a8\u8bcd\u6709\u65f6\u6001\u7684\u533a\u522b, \u533b\u5b66\u751f\u5728\u64b0\u5199\u8bba\u6587\u65f6\u5e38\u5ffd\u89c6\u8fd9\u4e00\u70b9, \u9020\u6210\u6587\u7ae0\u524d\u540e\u65f6\u6001\u4e0d\u4e00\u81f4, \u751a\u81f3\u51fa\u73b0\u4e00\u53e5\u8bdd\u4e00\u4e2a\u65f6\u6001\u751a\u81f3\u591a\u4e2a\u65f6\u6001\u7684\u73b0\u8c61\u3002\u7279\u522b\u503c\u5f97\u4e00\u63d0\u7684\u662f, \u5b66\u672f\u8bba\u6587\u7684\u65f6\u6001\u4e0e\u6211\u4eec\u6b63\u5e38\u7406\u89e3\u7684\u65f6\u95f4\u53d8\u5316\u6709\u5dee\u8ddd\u3002\u4e00\u822c\u8bf4\u6765, \u884c\u6587\u8981\u6c42\u4ee5\u201c\u8fc7\u53bb\u65f6\u6001\u53d9\u8ff0\u4f5c\u8005\u51c6\u5907\u5de5\u4f5c, \u7528\u73b0\u5728\u65f6\u6001\u53d9\u8ff0\u4f5c\u8005\u7ed3\u8bba\u201d , \u4f46\u662f\u5728\u5f15\u7528\u5148\u524d\u7814\u7a76\u7684\u89c2\u70b9\u6216\u7ed3\u8bba\u65f6, \u90fd\u7528\u4e00\u822c\u73b0\u5728\u65f6\u6216\u73b0\u5728\u5b8c\u6210\u65f6\u6765\u53d9\u8ff0,\u8fd9\u6837\u66f4\u80fd\u4f53\u73b0\u6240\u5f15\u8ff0\u7684\u5185\u5bb9\u662f\u4e00\u79cd\u5ba2\u89c2\u4e8b\u5b9e, \u6216\u8005\u662f\u4e00\u79cd\u771f\u7406\u6027\u7684\u5b58\u5728\u3002\u5728\u884c\u6587\u7684\u80cc\u666f\u4ecb\u7ecd\u4e0e\u8ba8\u8bba\u8fd9\u4e24\u90e8\u5206\u4e2d, \u53ef\u4f7f\u7528\u4e00\u822c\u73b0\u5728\u65f6\u548c\u73b0\u5728\u5b8c\u6210\u65f6, \u4e0d\u7528\u8003\u8651\u5148\u524d\u7814\u7a76\u65f6\u95f4, \u800c\u5728\u53d9\u8ff0\u4f5c\u8005\u6240\u505a\u7684\u7814\u7a76\u5de5\u4f5c\u65f6, \u591a\u7528\u4e00\u822c\u8fc7\u53bb\u65f6\u3002<\/p>\n<\/section>\n<\/section>\n<\/article>\n<\/section>\n
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\u00a0 \u00a0 \u00a0 \u00a0\u8f83\u591a\u7684\u4f7f\u7528\u4e0d\u5fc5\u8981\u7684\u53e5\u5b50\u6210\u4efd\u5f31\u5316\u4e86\u884c\u6587\u7684\u4e3b\u9898<\/p>\n<\/section>\n<\/section>\n
\u00a0 \u00a0 \u00a0 \u00a0\u82f1\u8bed\u884c\u6587\u591a\u4ee5\u4e2d\u5fc3\u5185\u5bb9\u6216\u91cd\u8981\u4e8b\u5b9e\u5f00\u5934\u5e76\u4f5c\u4e3a\u53e5\u5b50\u4e2d\u7684\u4e3b\u8bed, \u800c\u533b\u5b66\u751f\u4e60\u60ef\u4e8e\u4f7f\u7528It\u4f5c\u4e3a\u5f62\u5f0f\u4e3b\u8bed\u7684\u4e3b\u8bed\u4ece\u53e5\u4ee5\u53cathere be \u53e5\u578b, \u4f7f\u5f97\u6587\u7ae0\u7684\u4e2d\u5fc3\u5185\u5bb9\u4e0d\u7a81\u51fa\u3002\u4f8b\u5982:<\/p>\n

\u4f8b7 :It\u00a0has been widely\u00a0accepted\u00a0that PFS\u00a0is a\u00a0surrogate end point\u00a0for overall\u00a0survival in metastasis colorectal cancer.<\/p>\n

\u4f8b8:There\u00a0are some\u00a0relevance between initial\u00a0disease \u00a0control rate and overall survival .<\/p>\n

\u4f8b7\u4f7f\u7528\u4e86 It \u4f5c\u4e3a\u5f62\u5f0f\u4e3b\u8bed\u7684\u7ed3\u6784, \u4f8b8\u4e2d\u7684 There be<\/p>\n

\u7ed3\u6784\u5f31\u5316\u4e86\u5b66\u672f\u8bba\u6587\u5e94\u6709\u7684\u4e25\u8c28\u6027, \u5206\u522b\u4fee\u6539\u5982\u4e0b:<\/p>\n

PFS has been widely accepted as a surrogate end point for over- all survival in metastasis\u00a0colorectal\u00a0cancer.<\/p>\n

Initial disease control rate correlates with overall survival.<\/p>\n

\u4fee\u6539\u540e\u7684\u8868\u8fbe\u7b80\u6377\u660e\u4e86, \u9605\u8bfb\u4eba\u4e00\u4e0b\u5c31\u4e86\u89e3\u6587\u7ae0\u6240\u9610\u8ff0\u7684\u4e2d\u5fc3\u5185\u5bb9\u3002<\/p>\n<\/section>\n<\/section>\n<\/article>\n<\/section>\n

\n
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\u00a0 \u00a0 \u00a0 \u00a0\u533b\u5b66\u751f\u00a0SCI \u8bba\u6587\u5199\u4f5c\u7684\u5efa\u8bae<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/article>\n

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\u975e\u6bcd\u8bed\u5199\u4f5c\u672c\u8eab\u5c31\u5f88\u6709\u6311\u6218\u6027, \u53ea\u8981\u533b\u5b66\u751f\u5728\u51c6\u5907\u5b66\u672f\u5199\u4f5c\u65f6\u591a\u591a\u9605\u8bfb\u82f1\u8bed\u6587\u732e, \u638c\u63e1\u4e0a\u8ff0\u7684\u8bed\u8a00\u6280\u5de7\u5e76\u5e94\u7528\u5230\u5177\u4f53\u7684\u8bba\u6587\u5199\u4f5c\u5b9e\u8df5\u4e2d, \u5c31\u80fd\u5728\u5f88\u5927\u7684\u5c42\u9762\u4e0a\u4fdd\u8bc1\u5176\u5b66\u672f\u8bba\u6587\u4e0d\u5728\u8bed\u8a00\u7684\u5c42\u9762\u4e0a\u88ab\u62d2\u3002<\/p>\n

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