{"id":17,"date":"2017-02-14T10:12:12","date_gmt":"2017-02-14T02:12:12","guid":{"rendered":"http:\/\/www.ithenticate.com.cn\/news\/?p=17"},"modified":"2017-02-14T10:12:12","modified_gmt":"2017-02-14T02:12:12","slug":"%e9%ab%98%e7%a6%8f%e9%99%a2%e5%a3%ab%ef%bc%8c%e4%b8%a5%e6%99%af%e5%8d%8e%e7%a0%94%e7%a9%b6%e5%91%98%e8%bf%9e%e5%8f%91science%ef%bc%8cnature%e5%ad%90%e5%88%8a%e6%96%87%e7%ab%a0","status":"publish","type":"post","link":"https:\/\/www.ithenticate.com.cn\/news\/?p=17","title":{"rendered":"\u9ad8\u798f\u9662\u58eb\uff0c\u4e25\u666f\u534e\u7814\u7a76\u5458\u8fde\u53d1Science\uff0cNature\u5b50\u520a\u6587\u7ae0"},"content":{"rendered":"<div>\n<p>\u4e2d\u79d1\u9662\u5fae\u751f\u7269\u7814\u7a76\u6240\u4e25\u666f\u534e\u7814\u7a76\u5458\u4e0e\u9ad8\u798f\u9662\u58eb\u8fd1\u671f\u5408\u4f5c\u63a5\u8fde\u5728Nature Communications\uff0c\u4ee5\u53caScience Translational Medicine\u6742\u5fd7\u4e0a\u53d1\u8868\u6587\u7ae0\uff0c\u5206\u522b\u62a5\u9053\u4e86nivolumab\u963b\u65adPD-1\/PD-L1 \u76f8\u4e92\u4f5c\u7528\u6a21\u5f0f\u548cPD-1\u86cb\u767d\u7cd6\u57fa\u5316\u4fee\u9970\u5bf9\u5176\u7ed3\u5408 nivolumab \u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u9ad8\u6548\u3001\u7279\u5f02\u6027\u4eba\u6e90\u5be8\u5361\u75c5\u6bd2\uff08zika virus\uff0c ZIKV\uff09\u6cbb\u7597\u6027\u6297\u4f53\u53ca\u5176\u673a\u5236\u3002<\/p>\n<p>Nivolumab\u662f\u767e\u65f6\u7f8e-\u65bd\u8d35\u5b9d\u516c\u53f8\u5f00\u53d1\u7684 PD-1 \u9776\u5411\u6027\u6297\u4f53\u836f\u7269\uff0c\u4e8e2014\u5e74\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u52a0\u901f\u6279\u51c6\uff0c\u7528\u4e8e\u9ed1\u8272\u7d20\u7624\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7b49\u6076\u6027\u80bf\u7624\u7684\u6cbb\u7597\u3002\u5728\u7b2c\u4e00\u7bc7\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u7ec4\u6210\u5458\u53d1\u73b0\u4f4d\u4e8e PD-1 \u5206\u5b50\u80de\u5916\u514d\u75ab\u7403\u86cb\u767d\u529f\u80fd\u57df\u5916\u7684 N \u7aef loop \u533a\u57df\uff08N-loop\uff09\u4ecb\u5bfc\u4e86\u5176\u4e0e nivolumab \u4e3b\u8981\u7684\u6c22\u952e\u76f8\u4e92\u4f5c\u7528\uff0c\u800c\u901a\u8fc7\u8868\u9762\u7b49\u79bb\u5b50\u5171\u632f\u6280\u672f\uff08SPR\uff09\u5206\u6790 nivolumab \u4e0e PD-1 \u7684\u4eb2\u548c\u529b\uff0c\u53d1\u73b0 N-loop \u7f3a\u5931\u7684 PD-1 \u5b8c\u5168\u4e27\u5931\u4e86\u4e0e nivolumab \u7ed3\u5408\u7684\u80fd\u529b\uff0c\u56e0\u6b64\uff0cN-loop \u5728 PD-1 \u4e0e nivolumab \u76f8\u4e92\u4f5c\u7528\u4e2d\u53d1\u6325\u4e86\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/p>\n<p>Nivolumab \u7684\u4e34\u5e8a\u524d\u7814\u7a76\u62a5\u544a\u8868\u660e\u5176\u4e0e PD-1 \u7684\u7ed3\u5408\u53ef\u80fd\u4f9d\u8d56\u4e8e PD-1 \u7684\u7cd6\u57fa\u5316\u4fee\u9970\uff0c\u800c\u80bf\u7624\u7ec6\u80de\u5185\u6e90\u6027\u8868\u8fbe\u7684 PD-1 \u53ef\u80fd\u4f1a\u7531\u4e8e\u7cd6\u57fa\u8f6c\u79fb\u9176\u529f\u80fd\u5f02\u5e38\u800c\u5bfc\u81f4 PD-1 \u7cd6\u57fa\u5316\u4fee\u9970\u5f02\u5e38\uff0c\u4ece\u800c\u4f7f\u5f97 nivolumab \u6cbb\u7597\u6548\u679c\u53d7\u5230\u5f71\u54cd\uff0c\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u5bf9 PD-1 \u7684\u7cd6\u57fa\u5316\u4fee\u9970\u60c5\u51b5\u53ca\u5176\u5bf9 nivolumab \u76f8\u4e92\u4f5c\u7528\u7684\u5f71\u54cd\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u5728 PD-1 \u7684\u7ed3\u6784\u4e2d\u80fd\u591f\u89c2\u5bdf\u5230\u5176\u7b2c 58 \u4f4d\u5929\u51ac\u9170\u80fa\u7cd6\u57fa\u5316\u4fee\u9970\u4f4d\u70b9\u7684\u7cd6\u94fe\u4fee\u9970\uff0c\u7136\u800c\u901a\u8fc7 SPR \u5b9e\u9a8c\u5bf9 nivolumab \u4e0e PD-1 \u7684 4 \u4e2a N &#8211; \u7cd6\u57fa\u5316\u4f4d\u70b9\u5206\u522b\u7a81\u53d8\u540e\u86cb\u767d\u7684\u4eb2\u548c\u529b\u68c0\u6d4b\u663e\u793a\u5176\u4e0e\u91ce\u751f\u578b PD-1 \u86cb\u767d\u4eb2\u548c\u529b\u5e76\u65e0\u663e\u7740\u5dee\u5f02\u3002\u4e0d\u4ec5\u5982\u6b64\uff0cnivolumab \u4e0e\u65e0\u7cd6\u57fa\u4fee\u9970\u80fd\u529b\u7684\u539f\u6838\u7ec6\u80de\u53ca\u5dee\u5f02\u6027\u7cd6\u57fa\u4fee\u9970\u7684\u6606\u866b\u7ec6\u80de\u8868\u8fbe\u7684 PD-1 \u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u4eb2\u548c\u529b\u4e0e\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u8868\u8fbe\u4ea7\u751f\u7684 PD-1 \u65e0\u663e\u7740\u5dee\u5f02\uff0c\u8868\u660e nivolumab \u4e0e PD-1 \u7684\u76f8\u4e92\u4f5c\u7528\u5e76\u4e0d\u4f9d\u8d56\u4e8e PD-1 \u7684\u7cd6\u57fa\u5316\u4fee\u9970\u3002\u901a\u8fc7 nivolumab \u548c pembrolizumab \u4e0e PD-1 \u76f8\u4e92\u4f5c\u7528\u6a21\u5f0f\u7684\u6bd4\u8f83\u53d1\u73b0\uff0c\u4e8c\u8005\u7ed3\u5408 PD-1 \u4e0d\u540c\u533a\u57df\uff0c\u5c3d\u7ba1\u5176\u5728 PD-1 \u4e0a\u7684\u7ed3\u5408\u9762\u76f8\u4e92\u7d27\u90bb\uff0c\u4f46\u4e8c\u8005\u5e76\u672a\u53d1\u751f\u4ea4\u4e92\u91cd\u53e0\u3002\u901a\u8fc7 OCTEC \u5bf9\u4e8c\u8005\u7ade\u4e89 \/ \u534f\u540c\u7ed3\u5408\u7279\u6027\u8fdb\u884c\u5206\u6790\u8868\u660e\uff0cPD-1 \u7ed3\u5408 niovlumab \u540e\u4e0d\u80fd\u518d\u6709\u6548\u7ed3\u5408 pembrolizumab\uff0c\u53cd\u4e4b\u4ea6\u7136\u3002\u56e0\u6b64\uff0c\u5c3d\u7ba1 nivolumab \u548c pembrolizumab \u7ed3\u5408 PD-1 \u7684\u4e0d\u540c\u533a\u57df\uff0c\u5176\u7ed3\u5408 PD-1 \u540e\u4ea7\u751f\u7684\u7a7a\u95f4\u4f4d\u963b\u5bf9\u4e8e\u8fdb\u4e00\u6b65\u7ed3\u5408\u53e6\u4e00\u4e2a\u6297\u4f53\u5177\u6709\u4e00\u5b9a\u7a7a\u95f4\u4f4d\u963b\u6548\u5e94\u3002<\/p>\n<p>\u7b2c\u4e8c\u7bc7\u6587\u7ae0\u5219\u5728\u7814\u53d1\u5be8\u5361\u75c5\u6bd2\u6cbb\u7597\u6027\u6297\u4f53\u65b9\u9762\u53d6\u5f97\u91cd\u8981\u8fdb\u5c55\uff0c\u7387\u5148\u627e\u5230\u9ad8\u6548\u3001\u7279\u5f02\u6027\u4eba\u6e90\u5be8\u5361\u75c5\u6bd2\uff08zika virus\uff0c ZIKV\uff09\u6cbb\u7597\u6027\u6297\u4f53\u53ca\u5176\u673a\u5236\uff0c\u8be5\u6297\u4f53\u5728\u5c0f\u9f20\u6a21\u578b\u4e0a\u80fd\u6709\u6548\u6cbb\u7597ZIKV\u611f\u67d3\uff0c\u6709\u671b\u6210\u4e3a\u6cbb\u7597\u5176\u611f\u67d3\u7684\u5019\u9009\u836f\u7269\u3002<\/p>\n<p>\u968f\u7740\u7814\u7a76\u7684\u6df1\u5165\uff0cZIKV\u7684\u5371\u5bb3\u9010\u6e10\u88ab\u63ed\u793a\uff0c\u4ece\u6700\u521d\u7684\u53d1\u70e7\u3001\u76ae\u75b9\u7b49\u8f7b\u5fae\u75c7\u72b6\uff0c\u5230\u5f15\u8d77\u65b0\u751f\u513f\u5c0f\u5934\u75c7\u548c\u683c\u6797-\u5df4\u5229\u7efc\u5408\u5f81\u7b49\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u3002\u6700\u8fd1\u9ad8\u798f\u9662\u58eb\u56e2\u961f\u4e0eMichael Diamond\u6559\u6388\u56e2\u961f\u72ec\u7acb\u7814\u7a76\u5747\u63ed\u793a\uff0cZIKV\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u5f15\u8d77\u777e\u4e38\u635f\u4f24\u5e76\u6700\u7ec8\u5bfc\u81f4\u96c4\u6027\u4e0d\u80b2\u3002\u622a\u81f3\u76ee\u524d\u8fd8\u6ca1\u6709ZIKV\u75ab\u82d7\u53ca\u836f\u7269\u4e0a\u5e02\u3002<\/p>\n<p>ZIKV\u8868\u9762\u542b\u6709E\u86cb\u767d\uff08Envelope\uff09\uff0c\u542b\u6709\u4e09\u4e2a\u4e0d\u540c\u7684\u7ed3\u6784\u57df\uff08DI\uff0c DII\u548cDIII\uff09\u662f\u8d1f\u8d23\u53d7\u4f53\u8bc6\u522b\u4e0e\u819c\u878d\u5408\u7684\u91cd\u8981\u86cb\u767d\uff0c\u542b\u6709\u4ea7\u751f\u4e2d\u548c\u6297\u4f53\u7684\u91cd\u8981\u8868\u4f4d\u3002\u7814\u7a76\u56e2\u961f\u4ece\u4e00\u4f8b\u5357\u7f8e\u8f93\u5165\u75c5\u4f8b\u5165\u624b\uff0c\u91c7\u96c6\u5176\u5eb7\u590d\u540e\u7684\u8840\u6db2\u5e76\u5206\u79bbPBMCs\uff0c\u7136\u540e\u4ee5ZIKV 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Tan\uff0c Hao Zhang\uff0c Yan Chai et.al.<a href=\"http:\/\/http\/www.nature.com\/articles\/ncomms14369#auth-1\">An unexpected N-terminal loop in PD-1 dominates binding by nivolumab <\/a>Nature Communications 8\uff0c Article number\uff1a 14369 (2017)doi\uff1a10.1038\/ncomms14369<\/p>\n<p>Qihui Wang\uff0c Huabing Yang\uff0c Xiaoqing Liu4 et.al.Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus Science Translational Medicine \u00a014 Dec 2016\uff1aVol. 8\uff0c Issue 369\uff0c pp. 369ra179 DOI\uff1a 10.1126\/scitranslmed.aai8336<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u79d1\u9662\u5fae\u751f\u7269\u7814\u7a76\u6240\u4e25\u666f\u534e\u7814\u7a76\u5458\u4e0e\u9ad8\u798f\u9662\u58eb\u8fd1\u671f\u5408\u4f5c\u63a5\u8fde\u5728Nature Communications\uff0c\u4ee5\u53caScie 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