{"id":1012,"date":"2017-08-25T16:40:51","date_gmt":"2017-08-25T08:40:51","guid":{"rendered":"http:\/\/www.ithenticate.com.cn\/news\/?p=1012"},"modified":"2017-08-25T16:40:51","modified_gmt":"2017-08-25T08:40:51","slug":"introduction%e6%98%af%e4%b8%80%e7%af%87sci%e7%9a%84%e5%bc%95%e5%ad%90","status":"publish","type":"post","link":"https:\/\/www.ithenticate.com.cn\/news\/?p=1012","title":{"rendered":"Introduction\u662f\u4e00\u7bc7SCI\u7684\u5f15\u5b50"},"content":{"rendered":"

Introduction\uff0c\u6211\u4eec\u79f0\u4e4b\u4e3a\u5f15\u8a00\uff0c\u4e5f\u53eb\u8bba\u6587\u7684\u80cc\u666f\u4ecb\u7ecd\u3002\u5f15\u8a00\u662f\u4ecb\u7ecd\u8bfe\u9898\u7814\u7a76\u7684\u7531\u6765\uff0c\u4ee5\u53ca\u4e3a\u4ec0\u4e48\u63a2\u7a76\u8fd9\u4e2a\u8bfe\u9898\u7684\u539f\u7531\u3002\u4e00\u822c\u8fd9\u4e2a\u90e8\u5206\u7684\u5185\u5bb9\u8d77\u7740\u5f15\u5bfc\u8bfb\u8005\u6b63\u786e\u9605\u8bfb\u6587\u7ae0\u7684\u4f5c\u8005\uff0c\u6240\u4ee5\u6211\u4eec\u53c8\u8bf4\u5f15\u8a00\u662f\u4e00\u7bc7SCI\u7684\u5f15\u5b50\u3002\u00a0\"\"<\/a><\/p>\n

\u90a3\u4e48\u7a76\u7adf\u8981\u600e\u6837\u5199introduction\u5462?\u9996\u5148\u5e94\u8be5\u660e\u786e\u51e0\u4e2a\u57fa\u672c\u95ee\u9898\uff1a\u4f60\u60f3\u901a\u8fc7\u4e00\u7bc7\u8bba\u6587\u8bf4\u660e\u4ec0\u4e48\u95ee\u9898?\u8fd9\u4e2a\u8bba\u6587\u6709\u54ea\u4e9b\u65b0\u7684\u53d1\u73b0?\u6709\u4ec0\u4e48\u6837\u7684\u5b9e\u8df5\u610f\u4e49?\u8ba9\u8bfb\u8005\u8bfb\u4e86\u5f15\u8a00\uff0c\u5c31\u80fd\u6e05\u695a\u5730\u77e5\u9053\u4f5c\u8005\u4e3a\u4ec0\u4e48\u8fdb\u884c\u8fd9\u4e2a\u7814\u7a76\uff0c\u8fd8\u6709\u4e3a\u4ec0\u4e48\u8fd9\u7bc7\u6587\u7ae0\u503c\u5f97\u6211\u4eec\u770b\u4e0b\u53bb\u3002\u56e0\u6b64\uff0c\u5728\u5199\u5f15\u8a00\u4e4b\u524d\uff0c\u8981\u5c3d\u53ef\u80fd\u591a\u5730\u4e86\u89e3\u76f8\u5173\u7684\u5185\u5bb9\uff0c\u6536\u96c6\u524d\u4eba\u548c\u522b\u4eba\u5df2\u6709\u5de5\u4f5c\u7684\u4e3b\u8981\u8d44\u6599\uff0c\u5b8c\u5584\u6211\u4eec\u5c06\u8981\u5199\u51fa\u6765\u53d1\u8868\u7684\u7814\u7a76\u5185\u5bb9\u7684\u5408\u7406\u6027\u3002<\/p>\n

1\u3001\u6240\u5728\u7814\u7a76\u9886\u57df\u7684\u4ecb\u7ecd, \u7814\u7a76\u5927\u80cc\u666f\u3002\u6bd4\u5982\u80bf\u7624\u7814\u7a76\u6587\u7ae0\u4e2d\u5c31\u662f\u67d0\u79cd\u5177\u4f53cancer\u7684\u80cc\u666f\u4ecb\u7ecd\u3002\u5305\u62ec\u75be\u75c5\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u4e34\u5e8a\u6cbb\u7597\u96be\u5ea6\uff0c\u5bf9\u5176\u8fdb\u884c\u7814\u7a76\u7684\u5fc5\u8981\u6027\u548c\u7d27\u8feb\u6027\u7b49\u7b49\u3002\u5e38\u7528\u7684\u53e5\u5f0f\u6709\uff1axx tumor is a leading cause of cancer mortality in …\/The high mortality rate of xx tumor is in part due to lack of early detection of xx cancer marker\/Resistance to existing the rapies in xx tumor is a major problem in xx field.<\/p>\n

2\u3001\u7ec6\u5316\u7684\u7814\u7a76\u9886\u57df\u4ecb\u7ecd\u3002\u6bd4\u5982\u5177\u4f53\u8bfe\u9898\u6d89\u53ca\u5230\u7684\u4fe1\u53f7\u901a\u8def\u5728\u75be\u75c5\u7814\u7a76\u4e2d\u8fdb\u5c55\u7684\u4ecb\u7ecd\uff0c\u6216\u8005\u4f60\u8981\u7814\u7a76\u7684\u57fa\u56e0\u5728\u67d0\u79cd\u75be\u75c5\u4e2d\u4ee5\u524d\u6709\u600e\u6837\u7684\u62a5\u9053\u53d1\u73b0\uff0c\u8fd9\u4e9b\u5185\u5bb9\u90fd\u662f\u8fdb\u884c\u4e00\u9879\u7814\u7a76\u7684\u539f\u56e0\uff0c\u4e5f\u5c31\u662f\u6240\u8c13\u7814\u7a76\u5185\u5bb9\u7684\u5408\u7406\u6027\u3002\u5e38\u7528\u7684\u53e5\u5f0f\u6709\uff1aOne signaling pathway that has been a focus of active research in xxx disease is xxx\/Previous reports showed that xxx pathway is involved in the regulation of xxx disease via xxx protein\/xxx binding to xxx receptor(promoter) causes downstream activation ofthe xxx signaling, resulting in xxx disease.<\/p>\n

3\u3001\u9488\u5bf9\u6587\u4e2d\u63d0\u53ca\u7684\u5206\u5b50\u6216\u6982\u5ff5\u8fdb\u884c\u4ecb\u7ecd\u3002\u524d\u4eba\u5de5\u4f5c\u53d1\u73b0\u8fd9\u4e9b\u5206\u5b50\u6709\u54ea\u4e9b\u529f\u80fd\uff0c\u4f60\u7684\u7814\u7a76\u53c8\u548c\u522b\u4eba\u5de5\u4f5c\u6709\u54ea\u4e9b\u4e0d\u540c\u7b49\u7b49\uff0c\u6307\u51fa\u522b\u4eba\u5de5\u4f5c\u7684\u4e0d\u8db3\u548c\u7f3a\u9677\u5728\u54ea\u91cc\u3002\u5e38\u7528\u7684\u53e5\u5f0f\u6709\uff1aExtensive studies have focused on the role of xxx in xxx signaling pathway, however, some recent findings suggested that xxx might be involved in another important pathway\/Although xxx was reported to play a role in xxx progress, the down stream signaling mechanisms were not fully understood.<\/p>\n

4\u3001\u5bf9\u81ea\u5df1\u5de5\u4f5c\u5185\u5bb9\u7684\u5c0f\u7ed3\u3002\u8bb2\u8ff0\u6211\u4eec\u53d1\u73b0\u4e86\u4ec0\u4e48\uff0c\u6211\u4eec\u7684\u5de5\u4f5c\u610f\u4e49\u5728\u54ea\u91cc\u3002\u4e0d\u662f\u7b80\u5355\u7684\u590d\u5236\u6458\u8981\uff0c\u66f4\u591a\u7684\u5f3a\u8c03\u5de5\u4f5c\u610f\u4e49\u3002\u5e38\u7528\u7684\u53e5\u5f0f\u6709\uff1aIn the present study,we identified xxx\/Our studies demon strated that…, indicating that targetingxxx as a potential the rapeutic strategy for xxx disease.<\/p>\n

\u5176\u6b21\uff0c\u5f15\u6587\u5199\u4f5c\u7684\u57fa\u672c\u8981\u6c42\u3002<\/p>\n

(1)\u8a00\u7b80\u610f\u8d45\uff0c\u6761\u7406\u6e05\u695a\u3002\u4e00\u822c\u5728450\u5b57\u4ee5\u5185\uff0c2-4\u4e2a\u81ea\u7136\u6bb5\u3002<\/p>\n

(2)\u5c3d\u91cf\u51c6\u786e\u3001\u6e05\u695a\u4e14\u7b80\u6d01\u5730\u6307\u51fa\u7814\u7a76\u5bf9\u8c61\u7684\u672c\u8d28\u548c\u8303\u56f4\uff0c\u5bf9\u7814\u7a76\u80cc\u666f\u7684\u9610\u8ff0\u505a\u5230\u7e41\u7b80\u9002\u5ea6\u3002\u6587\u732e\u5f15\u7528\u548c\u6570\u636e\u63d0\u4f9b\u4e00\u5b9a\u8981\u51c6\u786e\u3002<\/p>\n

(3)\u5168\u9762\u6982\u62ec\u603b\u7ed3\u8be5\u9886\u57df\u8fc7\u53bb\u548c\u73b0\u5728\u7684\u72b6\u51b5\uff0c\u7279\u522b\u662f\u6700\u65b0\u8fdb\u5c55\u65b9\u9762\u3002\u4f18\u5148\u9009\u62e9\u5f15\u7528\u7684\u6587\u732e\u5305\u62ec\u76f8\u5173\u7814\u7a76\u4e2d\u539f\u59cb\u3001\u91cd\u8981\u548c\u6700\u5177\u8bf4\u670d\u529b\u7684\u6587\u732e\u3002\u907f\u514d\u4e0d\u6070\u5f53\u5730\u5927\u91cf\u201c\u81ea\u5f15\u201d\u3002\u5f15\u7528\u6587\u732e\u65f6\u4e0d\u8981\u539f\u6587\u6284\u5f55\uff0c\u8981\u7528\u81ea\u5df1\u7684\u8bdd\u603b\u7ed3\u63cf\u8ff0\u3002<\/p>\n

(4)\u91c7\u53d6\u9002\u5f53\u7684\u65b9\u5f0f\u5f3a\u8c03\u4f5c\u8005\u5728\u672c\u6b21\u7814\u7a76\u4e2d\u6700\u91cd\u8981\u7684\u53d1\u73b0\u6216\u8d21\u732e\uff0c\u8ba9\u8bfb\u8005\u987a\u7740\u903b\u8f91\u7684\u6f14\u8fdb\u9605\u8bfb\u8bba\u6587\u3002<\/p>\n

(5)\u89e3\u91ca\u4e13\u95e8\u672f\u8bed\u6216\u7f29\u5199\u8bcd\uff0c\u5e2e\u52a9\u7f16\u8f91\u3001\u5ba1\u7a3f\u4eba\u548c\u8bfb\u8005\u9605\u8bfb\u7a3f\u4ef6\u3002<\/p>\n

\u7b2c\u4e09\uff0c\u5982\u4f55\u5347\u534e\u5f15\u8a00\u7684\u5185\u5bb9\u5462\uff1f<\/p>\n

\u4e3b\u6d41\u9ad8\u5206SCI\u8bba\u6587\u90a3\u662f\u53ea\u53d1\u8868\u6709\u521b\u65b0\u6027\u6216\u8005\u524d\u6cbf\u9886\u57df\u7684\u7814\u7a76\u7ed3\u679c\u7684\uff0c\u56e0\u6b64\uff0c\u8981\u60f3\u8ba9\u81ea\u5df1\u7684\u8bfe\u9898\u53d1\u8868\u5728\u66f4\u597d\u7684\u6742\u5fd7\u4e0a\uff0c\u6700\u91cd\u8981\u7684\u4e00\u6b65\u5c31\u662f\u628a\u81ea\u5df1\u7684\u7814\u7a76\u610f\u4e49\u51f8\u663e\u51fa\u6765\u3002<\/p>\n

\u5982\u679c\u4f60\u7684\u8bfe\u9898\u521a\u597d\u662f\u70ed\u70b9\u9886\u57df\u7684\u7814\u7a76\u5185\u5bb9\uff0c\u90a3\u4e48\u597d\u529e\u4e86\uff0c\u6bd4\u5982\u505a\u80bf\u7624\uff0c\u5c31\u5f3a\u8c03\u80bf\u7624\u7684\u5371\u5bb3\uff0c\u6cbb\u7597\u7684\u96be\u70b9\uff0c\u603b\u5f52\u662f\u8981\u8868\u8fbe\u8fd9\u75c5\u592a\u4e25\u91cd\u4e86\uff0c\u6025\u9700\u6211\u4eec\u6765\u7814\u7a76\u5b83\u7684\u673a\u5236\u3001\u63a2\u7d22\u6cbb\u7597\u529e\u6cd5\u554a\uff0c\u53ea\u6709\u8fd9\u6837\u624d\u663e\u5f97\u54b1\u8fd9\u8bfe\u9898\u6709\u610f\u4e49\u4e0d\u662f~~~\u518d\u6bd4\u5982\u4f60\u505a\u4e86\u5f88\u9ad8\u7ea7\u7684CRISPR\/Cas9\uff0c\u8fd9\u4e1c\u4e1c\u73b0\u5728\u4eba\u4eba\u90fd\u5728\u7528\uff0c\u4e3a\u4e86\u907f\u514d\u843d\u5165\u4fd7\u5957\uff0c\u4f60\u5c31\u5f97\u5148\u8bf4\u8bf4\u8fd9\u6280\u672f\u7684\u4f18\u52bf\u5728\u54ea\uff0c\u4e3a\u561b\u4f60\u8981\u7528\u5b83\uff0c\u6709\u6ca1\u6709\u4ec0\u4e48\u6539\u826f\uff0c\u597d\u5904\u5728\u54ea\uff0c\u603b\u5f52\u4e0d\u80fd\u767d\u7528\u4e86\u9ad8\u7ea7\u7684\u6280\u672f\uff0c\u8981\u901a\u8fc7\u5f3a\u8c03CRISPR\u7684\u91cd\u8981\u6027\uff0c\u51f8\u663e\u4f60\u7684\u7814\u7a76\u7684\u91cd\u8981\u6027\uff0c\u7136\u540e\u8bba\u6587\u7684\u6574\u4f53\u610f\u4e49\u81ea\u7136\u5f97\u5230\u4e86\u5347\u534e\u3002<\/p>\n

\u4f46\u662f\u5982\u679c\u4f60\u7684\u8bfe\u9898\u5e76\u975e\u4ec0\u4e48\u70ed\u70b9\u9886\u57df\u7684\u7814\u7a76\u5185\u5bb9\uff0c\u8fd9\u65f6\u5019\u4e5f\u4e0d\u80fd\u653e\u5f03\u8fd9\u90e8\u5206\u7684\u8ffd\u6c42\uff0c\u4e00\u4e2a\u8bfe\u9898\u4e4b\u6240\u4ee5\u5b58\u5728\u603b\u662f\u6709\u610f\u4e49\u7684\uff0c\u5373\u4f7f\u6ca1\u6709\u7275\u626f\u67d0\u79cd\u75be\u75c5\uff0c\u4e5f\u53ef\u4ee5\u4e3a\u4eba\u7c7b\u63a2\u7d22\u672a\u77e5\u4e16\u754c\u4f5c\u51fa\u8d21\u732e\u3002\u6240\u4ee5\u6211\u4eec\u4ecd\u7136\u8981\u52aa\u529b\u5f3a\u8c03\u81ea\u5df1\u7814\u7a76\u7684\u5ba2\u89c2\u610f\u4e49\uff0c\u6216\u8005\u5bfb\u627e\u6709\u6f5c\u529b\u7684\u5e94\u7528\u610f\u4e49\u7b49\u3002<\/p>\n

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